岡山大学歯学部

English

業績集

ARCOCS (Since June 2013)

Edited Book

1) Takigawa M.(ed)
CCN Proteins: Methods and Protocols, Methods in Molecu

Book Chapter

1) Kubota, S. and Takigawa, M
CCN2. Encyclopedia of Signaling Molecules (Choi S. ed.), 2nd edition

2) Yamaai T, Takigawa M.
Gene Expression Analysis of CCN Proteins: Whole-Mount In Situ Hybridiz
Analy CCN Proteins: Met Methods , pp. 11-19. , 2017

3) Kawaki H, Kubota S, Takigawa M.
Analysis of Expression of CCN Family Genes in Skeletal Tissue-Derived
CCN Proteins: Met Methods , 33-41. , 2017

4) Kawaki H, Kubota S, Takigawa M.
Western Blotting Analysis of CCN Proteins in Calcified Tissues.
CCN Proteins: Met Methods , 43-51. , 2017

5) Kawaki H, Kubota S, Takigawa M.
Immunohistochemical Analysis of CCN Proteins in Calcified Tissues.
CCN Proteins: Met Methods , 53-62. , 2017

6) Nishida T, Kubota S, Takigawa M.
Production of Recombinant CCN2 Protein by Mammalian Cells.
CCN Proteins: Met Methods , 95-105. , 2017

7) Janune D, Takigawa M.
In Vitro Transfection with and Expression of CCN Family of Genes.
CCN Proteins: Met Methods , 107-113., 2017

8) Kubota S, Takigawa M.
Preparation of Module-Specific Antibodies Against CCN Family Members.
CCN Proteins: Met Methods , 115-126., 2017

9) Kubota S, Kawaki H, Takigawa M.
ELISA of CCN Family Proteins in Body Fluids Including Serum and Plasma
CCN Proteins: Met Methods , 127-138., 2017

10) Kawaki H, Kubota S, Takigawa M.
Analysis of Signaling Pathways Activated by CCN Proteins.
CCN Proteins: Met Methods , 139-143., 2017

11) Hoshijima M, Hattori T, Takigawa M.
Protocols for Screening for Binding Partners of CCN Proteins: Yeast Tw
CCN Proteins: Met Methods , 145-154., 2017

12) Kubota S, Kawaki H, Takigawa M.
Protocols for Screening Peptide Motifs Binding to CCN Family Proteins.
CCN Proteins: Met Methods , 155-167., 2017

13) Aoyama E, Takigawa M.
Evaluation of Molecular Interaction between CCN2 Protein and Its Bindi
CCN Proteins: Met Methods , 169-176 , 2017

14) Eguchi T, Kubota S, Takigawa M.
Promoter Analyses of CCN Genes.
CCN Proteins: Met Methods , 177-185., 2017

15) Kondo S, Kubota S, Takigawa M.
Analysis of Posttranscriptional Regulation of CCN Genes.
CCN Proteins: Met Methods , 187-209., 2017

16) Hattori T, Hoshijima M, Takigawa M.
Protein Imaging of CCN2 and CCN3 in Living Cells.
CCN Proteins: Met Methods , 211-215., 2017

17) Nishida T, Kubota S, Takigawa M.
Cell Biological Assays for Measuring Chondrogenic Activities of CCN2 P
CCN Proteins: Met Methods , 219-237., 2017

18) Shimo T, Takigawa M.
Cell Biological Assays for Measuring Angiogenic Activities of CCN Prot
CCN Proteins: Met Methods , 239-249., 2017

19) Nishida T, Kubota S, Takigawa M.
In Vivo Evaluation of Cartilage Regenerative Effects of CCN2 Protein.
CCN Proteins: Met Methods , 273-282., 2017

20) Hattori T, Itoh S, Takigawa M.
Generation and Analysis of Cartilage-Specific CCN2 Overexpression in T
CCN Proteins: Met Methods , 391-403., 2017

21) Kawata K, Kubota S, Takigawa M.
Analysis of Transcytosis of CCN2 by Chondrocytes.
CCN Proteins: Met Methods , 405-413., 2017

22) Shimo T, Yoshioka N, Takigawa M, Sasaki
Analysis of Pathological Activities of CCN Proteins in Bone Metastasis
CCN Proteins: Met Methods , 505-512., 2017

Review Articles

1) 久保田聡
ゲノムの風景
岡山歯学会雑誌 , 35 , 1-12 , 2016

2) Kubota S. and Takigawa M
Cellular and molecular actions of CCN2/CTGF and their role under physiological and pathologica
Clinical Science , 128, 181-96 , 2015

3) Kubota, S.
Lovastatin rescues human and mice cartilage disorders.
J. Cell. Commun. Signal. , in press. , in press, 2015

4) Satoshi Kubota,Aya Maeda-
New functional aspects of CCN2 revealed by trans-omic approaches.
J. Oral Biosciences , in press. , , 2015

5) Kubota, S., Maeda-Uematsu
New functional aspects of CCN2 revealed by trans-omic approaches.
J. Oral Biosci. , 57, 37-43 , 2015

6) Kubota, S., Takigawa, M.
Cellular and molecular acting of CCN2/CTGF and its role under physiological and pathological c
Clin Sci (Lond). , 128, 181-196 , 2015

7) Kubota, S.
Lovastatin rescues human and mice cartilage disorders.
J. Cell Commun. Signal. , in press , in press, 2015

8) 小崎健一
核酸医薬への応用を目指した癌関連microRNAの統合的スクリーニング.
岡山歯学会雑誌 , 34 , 1-10 , 2015

9) Kubota, S.
Lovastatin rescues human and mice cartilage disorders.
J. Cell. Commun. Signal. , 9 , 95 , 2015

10) 水口 一,窪木拓男
特集:コンピュータ支援による顎運動解析「貼付一体型睡眠時ブラキシズム検出・解析装置」
日本歯科理工学会機関誌DE(Dental Engineering , 34, 199-202 , 2015

11) 前川享子
認知症の原因疾患別食行動の特徴とケア
臨床老年看護 , 22 , 2-8 , 2015

12) Elad S, Raber-Durlacher J
Basic oral care for hematology-oncology patients and hematopoietic stem cell transplantation r
Support Care Cancer , 23 , 223-236 , 2015

13) 佐々木朗,曽我賢彦
オーラルヘルスケアのコンセプトと実際①大学病院における医学部と連携した歯学部での取り組み.
別冊ザ・クインテッセンス 口腔外科 YEAR BOOK , 別冊 , 47-51 , 2015

14) 大原 直也
結核菌の潜伏、持続感染の分子遺伝学
化学療法の領域 , 31 , 印刷中 , 2015

15) Kamioka H
Osteocyte
J Oral Bioscience , , in press, 2015

16) 上岡 寛
歯の移動と骨細胞の役割
Clinical Celcium , , in press, 2015

17) 此内浩信、浅海淳一
口腔外科・歯科領域の画像診断 放射線科医の日常臨床に役立つ知識 下顎の嚢胞性病変
臨床画像 , 31 , 819-833 , 2015

18) 佐々木朗,曽我賢彦
オーラルヘルスケアのコンセプトと実際①大学病院における医学部と連携した歯学部での取り組み
別冊ザ・クインテッセンス 口腔外科 YEAR BOOK , 別冊 , 47-51 , 2015

19) Oshima M, Tsuji T
Whole tooth regeneration as a future dental treatment.
Engineering Mineralized and Load Bearing Tiss , in press , in press, 2014

20) Kubota S. and Takigawa M.
The CCN family acting throughout the body
Recent research developments. Biomolecular C , 5, 477-494, 2013

21) Takigawa M
CCN2: A master regulator of the genesis of bone and cartilage
J.Cell Commun. Signal , 7, 191-201, 2013

Peer-Reviewed Original Articles

2017

1) Matsumoto-Nakano M, Fujita K, Takashima Y, Nagayama K, Ardin A
Randomized clinical trial of drinking oolong tea show inhibition of dental
Caries r , , 投稿中

2) Yanaka Y, Muramatsu T, Uetake H, Kozaki K and Inazawa J
miR-544a induces epithelial-mesenchymal transition through the activation
Carcinog , , in press

3) Fujiwara N, Inoue J, Kawano T, Tanimoto K, Kozaki K and Inazaw
MiR-634 activates the mitochondrial apoptosis pathway and enhances chemoth
Cancer R , , in press

4) Eguchi T, Calderwood SK, Takigawa M, Kubota S, Kozaki KI.
Intracellular MMP3 Promotes HSP Gene Expression in Collaboration With Chro
J Cell B , 118 43-51. , 2017

5) Ugawa Y, Yamamoto T, Kawamura M, Yamashiro K, Shimoe M, Tomika
Rho-kinase regulates extracellular matrix-mediated osteogenic differentiat
Cell Bio , 41651-658 , 2017

6) Sathi GA, Farahat M,?Hara ES, Taketa H, Nagatsuka H, Kuboki T
MCSF orchestrates branching morphogenesis in developing submandibular glan
J Cell S , 301559-69 , 2017

7) Farahat M, Sathi GA,?Hara ES, Taketa H, Kuboki T, Matsumoto T
MSCs feeder layers induce SMG self-organization and branching morphogenesi
PloS One , 12e0176453, 2017

8) Ono M, Oshima M, Ogawa M, Sonoyama W, Hara ES, Oida Y, Shinkaw
Practical whole-tooth restoration utilizing autologous bioengineered tooth
Sci Rep , 7 44522, 2017

9) Okada M, Nakai A, Hara ES, Taguchi T, Nakano T and Matsumoto T
Biocompatible nanostructured solid adhesivesfor biological soft tissues.
Acta Bio , In press , 2017

10) Takaya K, Higuchi H, Ishii-Maruhama M, Yabuki-Kawase A, Honda
Capnography Prevents Hypoxia during Sedation for Dental Treatment, A Rando
JDR Clin , 2 158-167 , 2017

11) Ekuni D, Yamane-Takeuchi M, Kataoka K, Yokoi A, Taniguchi-Taba
Validity of a New Kit Measuring Salivary Lactate Dehydrogenase Level for S
Dis Mar , 2017 9547956 , 2017

12) Yoneda T, Tomofuji T, Kunitomo M, Ekuni D, Irie K, Azuma T, Ma
Preventive Effects of Drinking Hydrogen-Rich Water on Gingival Oxidative S
Nutrient , 9 pii: E64, 2017

13) Kumiko Yoshihara, Noriyuki Nagaoka, Yukinori Maruo,Goro Nishig
Sandblasting may damage the surface ofcomposite CAD-CAM blocks
Dental M , 33 e124-135, 2017

14) Noriyuki Nagaoka, Kumiko Yoshihara, Victor Pinheiro Feitosa, Y
Chemical interaction mechanism of 10-MDP with zirconia
Scientif , 7 , 2017

15) Kumiko Yoshihara, Noriyuki Nagaoka, Yukinori Maruo, Hidehiko S
Bacterial adhesion not inhibited by ion-releasing bioactive glass filler
Dental M , 33 723-734 , 2017

16) Kunoh T, Matsumoto S, Nagaoka N, Kanashima S, Hino K, Uchida T
Amino group in Leptothrix sheath skeleton is responsible for direct deposi
Scientif , 7 , 2017

17) Ishikawa T, Toyama T, Nakamura Y, Tamada K, Shimizu H, Ninagawa S, OUPR transducer BBF2H7 allows export of type II collagen in a cargo- and de
J Cell B , 5 1761-177, 2017

18) El-Seoudi A, El Kader TA, Nishida T, Eguchi T, Aoyama E, Takigawa M,Catabolic effects of FGF-1 on chondrocytes and its possible role in osteoa
J Cell C , , 2017

2016

1) "Hara, C., Kubota, S., Nishida, T., Hiasa, M., Hattori, T., Aoyama, E., Moriyama, Y., Kamioka, H., Takigawa, M. "
Involvement of multiple CCN family members in platelets that support regeneration of joint tissues.
Mod. Rheumatol. ", " In press In press ", " 2016

2) "Murase, Y,, Hattori, T., Aoyama, E., Nishida, T., Maeda-Uematsu, A., Kawaki, H., Lyons, K. M., Sasaki, A., Takigawa, M., Kubota, S."
Role of CCN2 in amino acid metabolism of chondrocytes.
J. Cell Biochem. ", " 117 927-937 ", " 2016

3) "Takeuchi-Igarashi, H., Kubota, S., Tachibana, T., Murakashi, E., Takigawa, M., Okabe, M., Numabe, Y"
Matrix remodeling response of human periodontal tissue cells toward fibrosis upon nicotine exposure.
Odontology ", " 104 35-43 ", " 2016

4) "Kawai, M., Liu, N., Hattori, T., Kataoka, Y-H., Takigawa, M., Kubota, S., Yamamoto, T. and Ohura, K."
Sorcin expression in the epiphyseal growth plates of mice.
J. Hard Tissue Biol. ", " 25 57-62 ", " 2016

5) "Goro Nishigawa, Yukinori Maruo, Masao Irie, Naoto Maeda, Kumiko Yoshihara, Noriyuki Nagaoka, Takuya Matsumoto, Shogo Minagi"
Various Effects of Sandblasting of Dental Restorative Materials
PLOS ONE ", " 11 e0147077 ", " 2016

6) "Inokoshi M, Yoshihara K, Nagaoka N, Nakanishi M, De Munck J, Minakuchi S, Vanmeensel K, Zhang F, Yoshida Y, Vleugels J, Naert I, Van Meerbeek B"
Structural and Chemical Analysis of the Zirconia-Veneering Ceramic Interface
Journal of Dental Research ", " 95 102-109 ", " 2016

7) "Hara C, Kubota S, Nishida T, Hiasa M, Hattori T, Aoyama E, Moriyama Y, Kamioka H, Takigawa M."
Involvement of multiple CCN family members in platelets that support regeneration of joint tissues.
Mod Rheumatol. ", " 1-10. ", " 2016

8) "Matsumoto K, Shimo T, Kurio N, Okui T, Obata K, Masui M, Pang P, Horikiri Y, Sasaki A"
Expression and role of sonic hedgehog in the process of fracture healing with aging
In Vivo ", " 30 99-105 ", " 2016

9) "Yao M, Shimo T, Ono Y, Obata K, Yoshioka N, Sasaki A"
Successful treatment of osteonecrosis-induced fractured mandible with teriparatide therapy: A case report
"International Journal of Surgery Case Reports," ", " 21 151-3 ", " 2016

10) "Shimo T, Matsumoto K, Takabatake K, Aoyama E, Takebe Y, Ibaragi S, Okui T, Kurio N, Takada H, Obata K, Pang P, Iwamoto M, Nagatsuka H, Sasaki A"
The role of Sonic hedgehog signaling in osteoclastogenesis and jaw bone destruction
PLoS One ", " 11 e0151731 ", " 2016

11) "Yoshioka N, Shimo T, Ibaragi S, Sasaki A"
Autologous blood injection for the treatment of recurrent temporomandibular joint dislocation
Acta Med Okayama ", " 70 291-294 ", " 2016

12) "Shibata A, Ibaragi S, Mandai H, Tsumur a T, Kishimoto K, Okui T, Hassan NM, Shimo T, Omori K, Hu GF, Takashiba S, Suga S, Sasaki A"
Synthetic Terrein Inhibits Progression of Head and Neck Cancer by Suppressing Angiogenin Production.
Anticancer Res ", " 36 2161-2168 ", " 2016

13) "Masui M, Okui T, Shimo T, Takabatake K, Fukazawa T, Matsumoto K, Kurio N, Ibaragi S, Naomoto Y, Nagatsuka H, Sasaki A"
Novel Midkine Inhibitor iMDK Inhibits Tumor Growth and Angiogenesis in Oral Squamous Cell Carcinoma
Anticancer Res ", " 36 2775-2781 ", " 2016

14) "Kunisada Y, Shimo T, Masui M, Yoshioka N, Ibaragi S, Matsumoto K, Okui T, Kurio N, Domae S, Kishimoto K, Nishiyama A, Sasaki A"
Detection of sonic hedgehog in a patients undergoing with orthognathic surgery
"International Journal of Surgery Open," ", " 5 1-4 ", " 2016

15) "Ono Y, Shimo T, Shirafuji Y, Hamada T, Masui M, Obata K, Yao M, Kishimoto K, Sasaki A"
Drug-induced hypersensitivity syndrome caused by carbamazepine used for the treatment of trigeminal neuralgia
Case Reports in Dentistry ", " 2016 4605231 ", " 2016

16) "Obata K, Shimo T, Okui T, Matsumoto K, Takada H, Takabatake K, Kunisada Y, Ibaragi S, Nagatsuka H, Sasaki A"
Tachykinin Receptor 3 Distribution in human oral squamous cell carcinoma
Anticancer Res ", " 36 6335-6341 ", " 2016

17) "Shimo T1, Matsumoto K1, Takabatake K2, Aoyama E3, Takebe Y2, Ibaragi S1, Okui T1, Kurio N1, Takada H1, Obata K1, Pang P1, Iwamoto M4, Nagatsuka H2, Sasaki A1."
The Role of Sonic Hedgehog Signaling in Osteoclastogenesis and Jaw Bone Destruction.
PLoS One. ", " 23 e0151731. ", " 2016

18) "Yoshioka Y, Ono M, Maeda A, Kilts TM, Hara ES, Khattab H, Ueda J, Aoyama E, Oohashi T, Takigawa M, Young MF, Kuboki T."
CCN4/WISP-1 positively regulates chondrogenesis by controlling TGF-β3 function.
Bone. ", " 83 162-70 ", " 2016

19) "Janune D, Abd El Kader T, Aoyama E, Nishida T, Tabata Y, Kubota S, Takigawa M."
Novel role of CCN3 that maintains the differentiated phenotype of articular cartilage.
J Bone Miner Metab. ", " ", " 2016

20) "Nishida T, Kubota S, Aoyama E, Yamanaka N, Lyons KM, Takigawa M."
"Low-intensity pulsed ultrasound (LIPUS) treatment of cultured chondrocytes stimulates production of CCN family protein 2 (CCN2), a protein involved in the regeneration of articular cartilage: mechanism underlying this stimulation."
Osteoarthritis Cartilage. ", " ", " 2016

21) "Terayama R, Yamamoto Y, Kishimoto N, Tabata M, Maruhama K, Iida S, Sugimoto T"
Differential Changes in Neuronal Excitability in the Spinal Dorsal Horn After Spinal Nerve Ligation in Rats.
"Neurochem Res (2016) 41, 2880-2889." ", " 41 2880-2889 ", " 2016

22) "Hosaki-Takamiya R, Hashimoto M, Imai Y, Nishida T, Yamada N, Mori H, Tanaka T, Kawanabe N, Yamashiro T, Kamioka H"
Collagen production of osteoblasts revealed by ultra-high voltage electron microscopy.
J Bone Miner Metab. ", " 34 491-499 ", " 2016

23) "Wang Z, Odagaki N, Tanaka T, Hashimoto M, Nakamura M, Hayano S, Ishihara Y, Kawanabe N, Kamioka H"
Alternation in the gap-junctional intercellular communication capacity during the maturation of osteocytes in the embryonic chick calvaria.
Bone ", " 91 20-29 ", " 2016

24) "Murakami T, Kawanabe N, Kataoka T, Hoshijima M, Komori H, Fujisawa A, and Kamioka H"
"A Single-center, Open-label, Randomized Controlled Clinical Trial to Evaluate the Efficacy and Safety of the Indirect Bonding Technique."
Acta Med Okayama ", " 70 413-416 ", " 2016

25) "Hoshijima M, Hattori T, Takigawa M"
Protocols for Screening for Binding Partners of CCN Proteins: Yeast Two-Hybrid System.
Methods Mol Biol ", " 1489 145-154 ", " 2016

26) "Hattori T, Hoshijima M, Takigawa M"
Protein Imaging of CCN2 and CCN3 in Living Cells.
Methods Mol Biol ", " 1489 211-215 ", " 2016

27) "早野暁, 星島光博, 石川崇典, 上岡寛"
歯科矯正用アンカースクリューおよびオクルーザルスプリントを用いて咬合再構築を行った成人開咬症例
中四国矯歯会誌 ", " 28 95-103 ", " 2016

28) 池亀美華、村埜淑恵、國定勇希、服部淳彦、鈴木信雄、山本敏男
キンギョ鱗における多核破骨細胞形成に関する形態学的研究:筋肉内自家移植鱗を用いた解析.
岡山歯学会雑誌 ", " 35 37-42 ", " 2016

29) "Suzuki N, Hanmoto T, Yano S, Furusawa Y, Ikegame M, Tabuchi Y, Kondo T, Kitamura K, Endo M, Yamamoto T, Sekiguchi T, Urata M, Mikuni-Takagaki Y, Hattori A"
Low-intensity pulsed ultrasound induces apoptosis in osteoclasts: Fish scales are a suitable model for the analysis of bone metabolism by ultrasound.
Comparative Biochemistry and Physiology Part A: molecular & integrative physiology ", " 195 26-31 ", " 2016

30) "Ikegame M, Tabuchi Y, Furusawa Y, Kawai M, Hattori A, Kondo T, Yamamoto T"
Tensile stress stimulates the expression of osteogenic cytokines/growth factors and matricellular proteins in the mouse cranial suture at the site of osteoblast differentiation.
Biomedical Research ", " 37 117-126 ", " 2016

31) "Sogawa C, Ikegame M, Miyazaki I, Ara T, Imamura Y, Okusha Y, Ohyama K, Asanuma M, Sogawa N*, Yamamoto T, Kozaki K."
Changes in metallothionein isoform expression in the bones of ovariectomized rats.
Journal of Hard Tissue Biology ", " 25 21-26 ", " 2016

32) "Yamashiro K, Sato A, Okazaki F, Nakano M, Sawaki K, Hirata Y, Yamachika E, Iida S,?Takashiba S."
Medication-related osteonecrosis of the jaws caused lethal sepsis in an edentulous patient with multiple systemic factors.
Clin Case Rep ", " 5 97-103 ", " 2016

33) "Kakuta E, Nomura Y, Morozumi T, Nakagawa T, Nakamura T, Noguchi K, Yoshimura A, Hara Y, Fujise O, Nishimura F, Kono T, Umeda M, Fukuda M, Noguchi T, Yoshinari N, Fukaya C, Sekino S, Numabe Y, Sugano N, Ito K, Kobayashi H, Izumi Y, Takai H, Ogata Y, Takano S, Minabe M, Makino-Oi A, Saito A, Abe Y, Sato S, Suzuki F, Takahashi K, Sugaya T, Kawanami M, Hanada N,?Takashiba S, Yoshie H."
Assessing the progression of chronic periodontitis using subgingival pathogen levels: a 24-month prospective multicenter cohort study.
BMC Oral Health ", " 17 46 ", " 2016

34) "Yamashiro K, Nakano M, Sawaki K, Okazaki F, Hirata Y,?Takashiba S."
The potential of positron emission tomography/computerized tomography (PET/CT) scanning as a detector of high-risk patients with oral infection during preoperative staging.
Oral Surg Oral Med Oral Pathol Oral Radiol. ", " 122 242-249 ", " 2016

35) "Hongo S, Yamamoto T, Yamashiro K, Shimoe M, Tomikawa K, Ugawa Y, Kochi S, Ideguchi H, Maeda H,?Takashiba S."
Smad2 overexpression enhances adhesion of gingival epithelial cells.
Arch Oral Biol ", " 71 46-53 ", " 2016

36) "Shibata A, Ibaragi S, Mandai H, Tsumura T, Kishimoto K, Okui T, Hassan NM, Shimo T, Omori K, Hu GF,?Takashiba S, Suga S, Sasaki A."
Synthetic Terrein Inhibits Progression of Head and Neck Cancer by Suppressing Angiogenin Production.
Anticancer Res ", " 36 2161-2168 ", " 2016

37) "Morozumi T, Nakagawa T, Nomura Y, Sugaya T, Kawanami M, Suzuki F, Takahashi K, Abe Y, Sato S, Makino-Oi A, Saito A, Takano S, Minabe M, Nakayama Y, Ogata Y, Kobayashi H, Izumi Y, Sugano N, Ito K, Sekino S, Numabe Y, Fukaya C, Yoshinari N, Fukuda M, Noguchi T, Kono T, Umeda M, Fujise O, Nishimura F, Yoshimura A, Hara Y, Nakamura T, Noguchi K, Kakuta E, Hanada N,?Takashiba S, Yoshie H."
Salivary pathogen and serum antibody to assess the progression of chronic periodontitis: a 24-mo prospective multicenter cohort study.
J Periodontal Res ", " 51 768-778 ", " 2016

38) "Kitamura M, Akamatsu M, Kawanami M, Furuichi Y, Fujii T, Mori M, Kunimatsu K, Shimauchi H, Ogata Y, Yamamoto M, Nakagawa T, Sato S, Ito K, Ogasawara T, Izumi Y, Gomi K, Yamazaki K, Yoshie H, Fukuda M, Noguchi T,?Takashiba S, Kurihara H, Nagata T, Hamachi T, Maeda K, Yokota M, Sakagami R, Hara Y, Noguchi K, Furuuchi T, Sasano T, Imai E, Ohmae M, Koizumi H, Watanuki M, Murakami S."
"Randomized Placebo-Controlled and Controlled Non-Inferiority Phase III Trials Comparing Trafermin, a Recombinant Human Fibroblast Growth Factor 2, and Enamel Matrix Derivative in Periodontal Regeneration in Intrabony Defects."
J Bone Miner Res ", " 31 806-814 ", " 2016

39) "Perbal B, Lau L, Lyons K, Kubota S, Yeger H, Fisher G."
"Report on the 8th international workshop on the CCN family of genes - Nice November 3-8, 2015."
J. Cell. Commun. Signal. ", " 10 77-86 ", " 2016

40) "Yoshioka Y, Ono M, Maeda A, Kilts TM, Hara ES, Khattab H, Ueda J, Aoyama E, Oohashi T, Takigawa M, Young MF and Kuboki T."
CCN4/WISP-1 positively regulates chondrogenesis by controlling TGF-β3 function.
Bone ", " 83 162-170 ", " 2016

41) "Hara ES, Ono M, Yoshioka Y, Ueda J, Hazehara Y, Pham HT, Matsumoto T and Kuboki T."
Antagonistic Effects of Insulin and TGF-β3 during Chondrogenic Differentiation of Human BMSCs under a Minimal Amount of Factors.
Cells Tissues Organs ", " 201 88-96 ", " 2016

42) "Minakuchi H, Sogawa C, Miki H, Hara ES, Maekawa K, Sogawa N, Kitayama S, Matsuka Y, Clark GT and Kuboki T."
Sleep bruxism frequency and platelet serotonin transporter activities in young adult subjects.
Sleep Breath ", " 20 271-276 ", " 2016

43) "Huang Y, Matsumura Y, Hatano S, Noguchi N, Murakami T, Iwakura Y, Sun X, Ohara N, Yoshikai Y."
IL-21 inhibits IL-17A-producing γδ T-cell response after infection with Bacillus Calmette-Gu?rin via induction of apoptosis.
Innate Immun. ", " 22 588-597 ", " 2016

44) "Takeuchi A, Eto M, Tatsugami K, Shiota M, Yamada H, Kamiryo Y, Dejima T, Kashiwagi E, Kiyoshima K, Inokuchi J, Takahashi R, Yokomizo A, Ohara N, Yoshikai Y."
Antitumor activity of recombinant Bacille Calmette-Gu?rin secreting interleukin-15-Ag85B fusion protein against bladder cancer.
Int Immunopharmacol. ", " 35 327-331 ", " 2016

45) "Hatano S, Tamura T, Umemura M, Matsuzaki G, Ohara N, Yoshikai Y."
Recombinant Mycobacterium bovis bacillus Calmette-Gu?rin expressing Ag85B-IL-7 fusion protein enhances IL-17A-producing innate γδ T cells.
Vaccine ", " 34 2490-2495 ", " 2016

46) "Mimura H, Takaya T, Matsuda S, Nakano K, Muraoka R, Tomida M, Okafuji N, Fujii T, Kawakami T."
Functional Role of HSP47 in the Periodontal Ligament Subjected to Occlusal Overload in Mice
Int J Med Sci. ", " 13 248-254 ", " 2016

47) "Sakai K, Nakano K, Matsuda S, Tsujigiwa H, Ochiai T, Shoumura M, Osuga N, Hasegawa H, Kawakami T."
Pathological Analysis of Cell Differentiation in Cholesterol Granulomas Experimentally Induced in Mice
Int J Med Sci. ", " 13 220-224 ", " 2016

48) "Takebe Y, Tsujigiwa H, Katase N, Siar CH, Takabatake K, Fujii M, Tamamura R, Nakano K, Nagatsuka H"
Parenchyma-stromal interactions induce fibrosis by secreting CCN2 and promote osteoclastogenesis by stimulating RANKL and CD68 through activated TGF-β/BMP4 in ameloblastoma
J Oral Pathol Med. ", " 46 67-75 ", " 2016

49) "Matsuda S, Nakano K, Tsujigiwa H, Takabatake K, Okafuji N, Shoumura M, Osuga N, Nagatsuka H, Kawakami T"
Overview of Cytological Dynamics of Periodontal Ligament Inflammatory Lesions
International Journal of Dentistry and Oral Science ", " ", " 2016

50) "Hayashi T, Higuchi H, Tomoyasu Y, Ishii-Maruhama M, Maeda S, Miyawaki T:"
Effect of carbamazepine or phenytoin therapy on blood level of intravenously administered midazolam: a prospective cohort study
J Anesth ", " 30 166-169 ", " 2016

51) "Watanabe Y, Higuchi H, Ishii-Maruhama M, Honda Y, Yabuki-Kawase A, Yamane-Hirano A, Tomoyasu Y, Maeda S, Miyawaki T"
"Effect of a low dose of midazolam on high blood pressure in dental patients: a randomised, double-blind, placebo-controlled, two-centre study"
Br J Oral Maxillofac Surg ", " 54 443-448 ", " 2016

52) Eguchi T* and Kuboki T
Cellular Reprogramming Induced by Defined microRNA
Stem Cells Int. ", " ", " 2016

53) "Arai K, Eguchi T*, Rahman MM, Sakamoto R, Masuda N, Nakatsura T, Calderwood SK, Kozaki K, Itoh M."
A Novel High-Throughput 3D Screening System for EMT Inhibitors: A Pilot Screening Discovered the EMT Inhibitory Activity of CDK2 Inhibitor SU9516.
PLOS ONE ", " 11 ", " 2016

54) "Kataoka K, Ekuni D, Tomofuji T, Irie K, Kunitomo M, Uchida Y, Fukuhara D, Morita M. "
"Visualization of Oxidative Stress Induced by Experimental Periodontitis in Keap1-Dependent Oxidative Stress Detector-Luciferase Mice."
Int J Mol Sci. ", " 17 pii: E1907 ", " 2016

55) "Machida T, Tomofuji T, Maruyama T, Yoneda T, Ekuni D, Azuma T, Miyai H, Mizuno H, Kato H, Tsutsumi K, Uchida D, Takaki A, Okada H, Morita M."
"miR?1246 and miR?4644 in salivary exosome as potential biomarkers for pancreatobiliary tract cancer. "
Oncol Rep. ", " 36 2375-81 ", " 2016

56) "Kunitomo M, Ekuni D, Mizutani S, Tomofuji T, Irie K, Azuma T, Yamane M, Kataoka K, Taniguchi-Tabata A, Mizuno H, Miyai H, Iwasaki Y, Morita M. "
"Association between Knowledge about Comprehensive Food Education and Increase in Dental Caries in Japanese University Students: A Prospective Cohort Study."
Nutrients. ", " 8 114 ", " 2016

57) "Tomofuji T, Yoneda T, Machida T, Ekuni D, Azuma T, Kataoka K, Maruyama T, Morita M. "
MicroRNAs as serum biomarkers for periodontitis.
J Clin Periodontol. ", " 43 418-425 ", " 2016

58) "Takeuchi-Igarashi H, Kubota S, Tachibana T, Murakashi E, Takigawa M, Okabe M, Numabe Y."
Matrix remodeling response of human periodontal tissue cells toward fibrosis upon nicotine exposure.
Odontology ", " 104 35-43 ", " 2016

59) "Yoshioka Y, Ono M, Maeda A, Kilts TM, Hara ES, Khattab H, Ueda J, Aoyama E, Oohashi T, Takigawa M, Young MF, Kuboki T."
CCN4/WISP-1 positively regulates chondrogenesis by controlling TGF-β3 function
Bone ", " 83 162-170 ", " 2016

60) " Murase Y, Hattori T, Aoyama E, Nishida T, Maeda-Uematsu A, Kawaki H, Lyons KM, Sasaki A, Takigawa M, Kubota S."
Role of CCN2 in Amino Acid Metabolism of Chondrocytes
J Cell Biochem. ", " 117 927-937 ", " 2016

61) "Hara C, Kubota S, Nishida T, Hiasa M, Hattori T, Aoyama E, Moriyama Y, Kamioka H, Takigawa M."
Involvement of multiple CCN family members in platelets that support regeneration of joint tissues.
Mod Rheumatol ", " 26 1-32 ", " 2016

62) "Eguchi T, Calderwood SK, Takigawa M, Kubota S, Kozaki K."
Intracellular MMP3 promotes HSP gene expression in collaboration with chromobox proteins
J Cell Biochem. ", " ", " 2016

63) "Nishida T, Kubota S, Aoyama E, Yamanaka N, Lyons KM, Takigawa M."
"Low-intensity pulsed ultrasound (LIPUS) treatment of cultured chondrocytes stimulates production of CCN family protein 2 (CCN2), a protein involved in the regeneration of articular cartilage: Mechanism underlying this stimulation."
Osteoarthritis Cartilage ", " S1063-4584(16)30311-9 ", " 2016

64) " Janune D, Abd El Kader T, Aoyama E, Nishida T, Tabata Y, Kubota S, Takigawa M."
Novel role of CCN3 that maintains the differentiated phenotype of articular cartilage
J Bone Miner Metab. ", " Epub ahead of print ", " 2016

2015

1) "Fujiwara N, Ohara N, Ogawa M, Maeda S, Naka T, Taniguchi H, Yamamoto S, Ayata M. "
Glycopeptidolipid of Mycobacterium smegmatis J15cs affects morphology and survival in host cells.
PLoS One ", " 10 e0126813 ", " 2015

2) "Yoshihara K, Nagaoka N, Okihara T, Kuroboshi M, Hayakawa S, Maruo Y, Nishigawa G, De Munck J, Yoshida Y, Van Meerbeek B"
Functional monomer impurity affects adhesive performance
Dental Materials ", " 31 1493-1501 ", " 2015

3) "Irie K, Tomofuji T, Ekuni D, Morita M, Shimazaki Y, Darveau RP. "
Impact of oral commensal bacteria on degradation of periodontal connective tissue.
J Periodontol ", " in press. ", " 2015

4) "Mizutani S, Ekuni D, Tomofuji T, Irie K, Azuma T, Iwasaki Y, Morita M. "
Structural equation modeling to assess gender differences in the relationship between psychological symptoms and dental visits after dental check-ups for university students.
Acta Odontologica Scandinavica ", " in press. ", " 2015

5) "Hoshijima M, Honjo T, Moritani N, Iida S, Yamashiro T, Kamioka H"
Maxillary Advancement for Unilateral Crossbite in a Patient with Sleep Apnea Syndrome
JActa Med Okayama ", " 69 177-82. ", " 2015

6) 友藤孝明,片岡広太,川端勇也,水谷慎介,江國大輔,森田 学.
塩化セチルピリジニウム配合トローチ剤の口臭抑制効果.
日本口臭学会会誌 ", " 印刷中. ", " 2015

7) "R. Terayama, Y. Yamamoto, N. Kishimoto, K. Maruhama, Mizutani, S. Iida, T. Sugimoto."
Peripheral nerve injury activates convergent nociceptive input to dorsal horn neurons from neighboring intact nerve.
Exp Brain Res ", " 233 1201-1212. ", " 2015

8) "Khattab HM, Aoyama E, Kubota S, Takigawa M."
Physical interaction of CCN2 with diverse growth factors involved in chondrocyte differentiation during endochondral ossification.
J Cell Commun Signal. ", " 19 [Epub ahead of print] ", " 2015

9) "R. Terayama, H. Tsuchiya, S. Omura, K. Maruhama, Mizutani, S. Iida, T. Sugimoto."
Possible Involvement of Convergent Nociceptive Input to Medullary Dorsal Horn Neurons in Intraoral Hyperalgesia Following Peripheral Nerve Injury.
Cell Mol Neurobiol ", " 35 417-423. ", " 2015

10) "Emilio Satoshi Hara, Mitsuaki Ono, Pham Thanh Hai, Wataru Sonoyama, Satoshi Kubota, Masaharu Takigawa, Takuya Matsumoto, Marian F. Young, Bjorn R. Olsen, Takuo Kuboki"
Fluocinolone acetonide is a potent synergistic factor of TGF-β3-associated chondrogenesis of bone marrow-derived mesenchymal stem cells for articular surface regeneration.
Bone Miner Res ", " in press ", " 2015

11) " Mizutani S, Ekuni D, Tomofuji T, Azuma T, Kataoka K, Yamane M, Iwasaki Y, Morita M. "
Relationship between xerostomia and gingival condition in young adults.
Journal of Periodontal Research ", " 50 74-9. ", " 2015

12) "Nishida T, Kubota S, Aoyama E, Janune D, Lyons KM, Takigawa M."
" CCN family protein 2 (CCN2) promotes the early differentiation, but inhibits the terminal differentiation of skeletal myoblasts."
J Biochem ", " 157 91-100 ", " 2015

13) "Tsuyoshi Shimo*, Mayumi Yao, Yuichiro Takebe, Yuko Ono, Kyoichi Obata, Naito Kurio, Soichiro Ibaragi, Norie Yoshioka, Koji Kishimoto, Yoshinobu Yanagi, Hitoshi Nagatsuka, Akira Sasaki."
" A case of adenoid cystic carcinoma associated with IgG4-related disease, International"
Journal of Surgery Case Reports ", " 10 1012-16 ", " 2015

14) "Yokoi A, Maruyama T, Yamanaka R, Ekuni D, Tomofuji T, Kashiwazaki H, Yamazaki Y, Morita M. "
Relationship between acetaldehyde concentration in mouth air and oral condition: pilot study using new portable monitor.
Journal of Applied Oral Sciences ", " 23 64-70. ", " 2015

15) "Onozawa S, Kikuchi Y, Shibayama K, Kokubu E, Nakayama M, Inoue T, Nakano K, Shibata Y, Ohara N, Nakayama K, Ishihara K, Kawakami T, Hasegawa H. "
Role of extracytoplasmic function sigma factors in biofilm formation of Porphyromonas gingivalis.
BMC Oral Health. ", " 17 4 ", " 2015

16) "? Kataoka K, Ekuni D, Mizutani S, Tomofuji T, Azuma T, Yamane M, Kawabata Y, Iwasaki Y, Morita M. "
Relationship between self-reported bruxism and malocclusion in university students: A cross-sectional study.
J Epidemiol ", " in press. ", " 2015

17) "Taguchi Y, Sato K, Yukitake H, Inoue T, Nakayama M, Naito M, Kondo Y, Kano K, Hoshino T, Nakayama K, Takashiba S and Ohara N"
"Involvement of a Skp-like protein, PGN_0300, in the type IX secretion system of Porphyromonas gingivalis"
Infect Immun ", " 84 230-240 ", " 2015

18) "Inoue T, Nakayama M, Taguchi Y, Kano K, Ono M, Shimizu Y, Kuroda T and Ohara N"
Characterization of the tripartite drug efflux pumps of Porphyromonas gingivalis ATCC 33277.
New Microbiol ", " 38 101-108 ", " 2015

19) "Wada T, Maruyama F, Iwamoto T, Maeda S, Yamamoto T, Nakagawa I, Yamamoto S and Ohara N"
Deep sequencing analysis of the heterogeneity of seed and commercial lots of the bacillus Calmette-Gu?rin (BCG) tuberculosis vaccine
Sci Rep ", " 5 17827 ", " 2015

20) "Chen C, Akiyama K, Wang D, Xu X, Li B, Moshaverinia A, Brombacher F, Sun L, Shi S. "
mTOR inhibition rescues osteopenia in mice with systemic sclerosis.
Journal of Experimental Med. ", " 212 73-91 ", " 2015

21) "Terayama R, Kishimoto N, Yamamoto Y, Maruhama K, Tsuchiya H, Mizutani M, Iida S, Sugimoto T"
Convergent nociceptive input to spinal dorsal horn neurons after peripheral nerve injury.
Neurochem Res ", " 40 438-445 ", " 2015

22) "Yamamoto Y, Terayama R, Kishimoto N, Maruhama K, Mizutani M, Iida S, Sugimoto T"
Activated Microglia Contribute to Convergent Nociceptive Inputs to Spinal Dorsal Horn Neurons and the Development of Neuropathic Pain.
Neurochem Res ", " 40 1000-1012 ", " 2015

23) "Maeda A, Ono M, Holmbeck K, Li L, Kilts TM, Kram V, Noonan ML, Yoshioka Y, McNerny EMB, Tantillo MA, Kohn DH, Lyons KM, Robey PG, Young MF"
"WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling"
The Journal of Biological Chemistry ", " 290 14004?14018 ", " 2015

24) "Yoshioka Y, Maeda A, Kilts TM,Hara ES, Khattab H, Ueda J, Aoyama E, Oohashi T, Takigawa M, Young MF, Kuboki T"
"CCN4/WISP-1 positively regulates chondrogenesis by controlling TGF-3 function. "
Bone ", " under review ", " 2015

25) "村田 尚道, 山本 昌直, 小林 幸生, 前川 享子, 東 倫子, 森 貴幸, 江草 正彦"
筋萎縮性側索硬化症における摂食嚥下障害の特徴
日本老年歯科医学会雑誌 ", " 29 350-356 ", " 2015

26) "吉田 登志子, 山中 玲子, 菅原 康代, 伊原木 聰一郎, 村上 隆, 村田 尚道, 志茂 剛, 柳田 剛志, 縄稚 久美子, 星加 知宏"
早期見学実習の一環として実施した振り返りを取り入れたエスコート実習の評価 過去8年間の検討
日本司会学教育学会雑誌 ", " 31 16-24 ", " 2015

27) "宗 淳一, 豊岡 伸一, 足羽 孝子, 小林 求, 福田 智美, 村田 尚道, 井上 真一郎, 牧 佑歩, 三好 新一郎"
呼吸器外科領域における周術期管理について
臨床呼吸生理 ", " 47 21-25 ", " 2015

28) "C. FUKUIKE, N. KODAMA, Y. MANDA, Y. HASHIMOTO, K. SUGIMOTO,A. HIRATA, Q. PAN, N. MAEDA and S. MINAGI"
A novel automated detection system for swallowing sounds during eating and speech under everyday conditions
J Oral Rehabil. ", " 42 340-347 ", " 2015

29) "Taketa H, Gulsan Ara Sathi, Mahmoud Farahat, Kazi Anisur Rahman, Sakai T, Hirano Y, Kuboki T, Torii Y and Matsumoto T."
Peptide-modified Substrate for Modulating Gland Tissue Growth and Morphology In Vitro
Scientific Reports ", " 11468 ", " 2015

30) "Kazi Anisur Rahman, Gulsan Ara Sathi, Taketa H, Mahmoud Farahat, Okada M, Torii Y and Matsumoto T."
Novel 3D - Printed Device for the Simple Preparation of Hydrogel Beads.
3D Printing ", " 5-11 ", " 2015

31) "Yokoi A, Maruyama T, Yamanaka R, Ekuni D, Tomofuji T, Kashiwazaki H, Yamazaki Y, Morita M"
Relationship between acetaldehyde concentration in mouth air and tongue coating volume.
J Appl Oral Sci ", " 23 64-70 ", " 2015

32) "吉田 登志子,山中 玲子, 菅原 康代, 伊原木 聰一郎, 村上 隆, 村田 尚道, 志茂 剛, 柳田 剛志, 縄稚 久美子, 星加 知宏"
早期見学実習の一環として実施した振り返りを取り入れたエスコート実習の評価 過去8年間の検討.
日本歯科医学教育学会雑誌 ", " 31 16-24 ", " 2015

33) "Goda Y, Matsumura T, Yanagi Y, Moritani N and Iida S"
Anatomical relationship between the mandibular foramen and the lateral surface shape of the mandibular ramus using CT.
"Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology" ", " in press ", " 2015

34) "Ikeda A, Yamachika E, Matsumura T, Mizutani M, Matsui Y and Iida S"
A case of diffuse sclerotic ostemyelitis of the mandible associated with SAPHO syndrome successfully treated with an oral bisphosphonate.
"Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology" ", " in press ", " 2015

35) "Nishida, T., Kubota, S., Aoyama, E., Janune, D., Lyons, K. M., Takigawa, M.:"
"CCN family protein 2 (CCN2) promotes the early differentiation, but inhibits the terminal differentiation of skeletal myoblasts. "
"J,Biochem," ", " 157 91-100 ", " 2015

36) "Aoyama, E., Kubota, S., Khattab, H. M., Nishida, T., Takigawa, M.:"
CCN2 enhances RANKL-induced osteoclast differentiation via direct binding to RANK and OPG.
Bone ", " 73 242-248 ", " 2015

37) "Hara, E. S., Ono, M., Hai, P. T., Sonoyama, W., Kubota, S., Takigawa, M., Matsumoto, T., Young, M. F., Olsen, B. R., Kuboki, T."
Fluoinolone acetonide is a potent synergistic factor of TGF-β3-associated chondrogenesis of bone marrow-derived mesenchymal stem cells for articular surface regeneration.
J. Bone Miner. Res. ", " in press in press ", " 2015

38) "Park, J., Gebhardt, M., Golovchenko, S., Perez Branguli, F., Hattori, T., Hartmann, C., Zhou, X., de Crombrugghe, B., Stock, M., Schneider, H., von der Mark, K."
Dual pathways to endochondral osteoblasts: A novel chondrocyte-derived cell identified in hypertrophic cartilage.
Biology Open ", " in press in press ", " 2015

39) "Khattab, H.M., Aoyama, E., Kubota, S., Takigawa, M."
Physical interaction of CCN2 with diverse growth factors involved in chondrocyte differentiation during endochondral ossification.
J. Cell Commun. Signal. ", " in press in press ", " 2015

40) "Takeuchi-Igarashi, H., Kubota, S., Tachibana, T., Murakashi, E., Takigawa, M., Okabe, M., Numabe, Y.: "
Matrix remodeling response of human periodontal tissue cells toward fibrosis upon nicotine exposure.
Odontology ", " in press in press ", " 2015

41) "Murase, Y., Hattori T., Aoyama, E., Nishida, T., Maeda-Uematsu, A, Kawaki, H., Lyons, K.M., Sasaki, A., Takigawa, M., Kubota, S."
Role of CCN2 in amino acid metabolism of chondrocytes
J. Cell. Biochem. ", " submitted submitted ", " 2015

42) "Hara, C., Kubota, S., Nishida,T., Hiasa, M., Hattori, T., Aoyama, E., Moriyama, Y., Kamioka, H., Takigawa, M."
Matricellular CCN family proteins in platelets: Possible roles in bone and cartilage regeneration
Matrix Biol. ", " submitted submitted ", " 2015

43) "Nakayama M, Inoue T, Naito M, Nakayama K and Ohara N"
"Attenuation of the phosphatidylinositol 3-kinase/Akt signaling pathway by Porphyromonas gingivalis gingipains RgpA, RgpB, and Kgp."
J Biol Chem ", " 290 5190-5202 ", " 2015

44) "Onozawa S, Kikuchi Y, Shibayama K, Kokubu E, Nakayama M, Inoue T, Nakano K, Shibata Y, Ohara N, Nakayama K, Ishihara K, Kawakami T and Hasegawa H"
Role of extracytoplasmic function sigma factors in biofilm formation of Porphyromonas gingivalis.
BMC Oral Health ", " 15 1-7 ", " 2015

45) "Fujiwara N, Ohara N, Ogawa M, Maeda S, Naka T, Taniguchi H, Yamamoto S and Ayata M"
Glycopeptidolipid of Mycobacterium smegmatis J15cs affects morphology and survival in host cells.
PLoS One ", " 10 0126813 ", " 2015

46) "Taguchi Y, Sato K, Yukitake H, Inoue T, Nakayama M, Naito M, Kondo Y, Kano K, Hoshino T, Nakayama K, Takashiba S and Ohara N"
"Involvement of a Skp-like protein, PGN_0300, in the type IX secretion system of Porphyromonas gingivalis"
Infect Immun ", " 投稿中 ", " 2015

47) "Wada T, Maruyama F, Iwamoto T, Maeda S, Yamamoto T, Nakagawa I, Yamamoto S and Ohara N"
Deep sequencing analysis of the heterogeneity of seed and commercial lots of the bacillus Calmette-Gu?rin (BCG) tuberculosis vaccine
Sci Rep ", " 投稿中 ", " 2015

48) "Onozawa S, Kikuchi Y, Shibayama K, Kokubu E, Nakayama M, Inoue T, Nakano K, Shibata Y, Ohara N, Nakayama K, Ishihara K, Kawakami T, and Hasegawa H "
Role of extracytoplasmic function sigma factors in biofilm formation of Porphyromonas gingivalis
BMC Oral Health ", " 15 1-7 ", " 2015

49) "Takaya T, Mimura H, Matsuda S, Nakano K, Tsujigiwa H, Tomida M, Okafuji N, Fujii T, and Kawakami T"
Cytological Kinetics of Periodontal Ligament in an Experimental Occlusal Trauma Model
Int J Med Sci ", " 12 544-551 ", " 2015

50) "Kaneko K, Matsuda S, Muraok R, Nakano K, Iwasaki T, Tomida M, Tsujigiwa H, Nagatsuka H, and Kawakami T"
Histological Evaluation of Periodontal Ligament in Response to Orthodontic Mechanical Stress in Mice
Int J Med Sci ", " 12 689-694 ", " 2015

51) "Kawanabe N, Fukushima H, Ishihara Y, Yanagita T, Kurosaka H and Yamashiro Y "
Isolation and characterization of SSEA-4-positive subpopulation of human deciduous dental pulp cells
Clinical Oral Investigatioins ", " 19 363-371 ", " 2015

52) "Islam MN, Itoh S, Yanagita T, Sumiyoshi K, Hayano S, Kuremoto K, Kurosaka H, Honjo T, Kawanabe N, Kamioka H, Sakai T, Ishimaru N, Taniuchi I and Yamashiro T"
Runx/Cbfb signaling regulates postnatal development of granular convoluted tubule in the mouse submandibular gland
Dev Dyn ", " 488-496 ", " 2015

53) "Deguchi T, Terao F, Aonuma T, Kataoka T, Sugawara Y, Yamashiro T and Takano-Yamamoto T"
"Outcome assessment of lingual and labial appliances compared with cephalometric analysis, peer assesment rating, and objective grading system in Angle Class II extraction cases"
Angle Orthod ", " 85 400-407 ", " 2015

54) "Hayano S, Komatsu Y, Pan H and Mishina Y"
Augmented BMP signaling in the neural crest inhibits nasal cartilage morphogenesis by inducing p53-mediated apoptosis
Development ", " 142 1357-1367 ", " 2015

55) "Hosaki-Takamiya R, Hashimoto M, Imai Y, Nishida T, Yamada N, Mori H, Tanaka T, Kawanabe N, Yamashiro T and Kamioka H"
Collagen production of osteoblasts revealed by ultra-high voltage electron microscopy
Journal of Bone and Mineral Metabolism ", " ", " 2015

56) "Ishimoto K, Hayano S, Yanagita T, Kurosaka H, Kawanabe N, Itoh S, Ono M, Kuboki T, Kamioka H and Yamashiro T "
Topical Application of Lithium Chloride on the Pulp Induces Dentin Regeneration
PLOS ONE ", " ", " 2015

57) "Murakami T, Kataoka T, Tagawa J, Yamashiro T and Hiroshi Kamioka"
Vertical skeletal variations influence the esthetic preference of the anteroposterior lip positions
Eiropean Journal of Orthodontics ", " 投稿中 in press ", " 2015

58) "Agarwal S, Loder SJ, Brownley C, Eboda O, Peterson JR, Hayano S, Wu B, Zhao B, Kaartinen V, Wong VC, Mishina Y, Levi B."
BMP signaling mediated by constitutively active Activin type 1 receptor (ACVR1) results in ectopic bone formation localized to distal extremity joints.
Dev Biol ", " 400 202-209 ", " 2015

59) 吉田登志子、山中玲子、菅原康代、伊原木聰一郎、村上 隆、村田尚道、志茂 剛、柳田剛志、縄稚久美子、星加知宏
早期見学実習の一環として実施した振り返りを取り入れたエスコート実習の評価-過去8年間の検討-
日本歯科医学教育学会雑誌 ", " 31 ", " 2015

60) "Unetsubo T, Matsuzaki H, Takemoto M, Katsui K, Hara M, Katayama N, Waki T, Kanazawa S, Asaumi J"
High-dose-rate brachytherapy using molds for lip and oral cavity tumors.
Radiat Oncol ", " 10 81 ", " 2015

61) "Maeda S, Tomayasu Y, Higuchi H, Honda Y, Ishii-Maruhama M, Miyawaki T."
Female patients require a higher propofol infusion rate for sedation
Anesth Prog ", " in press ", " 2015

62) "Hayashi T, Higuchi H, Tomoyasu Y, Ishii-Maruhama Y, Maeda S, Miyawaki T."
Effect on blood level of intravenously administered midazolam in patients receiving carbamazepine or phenytoin therapy: A prospective cohort study
J Anesth ", " in press ", " 2015

63) "Honda Y, Higuchi H, Matsuoka Y, Yabuki-Kawase A, Ishii-Maruhama M, Tomoyasu Y, Maeda S, Morimatsu H, Miyawaki T."
The inhibitory effect of locally injected dexmedetomidine on carrageenan-induced nociception in rats.
Eur J Pharmacol ", " 764 215-219 ", " 2015

64) "Maeda S, Tomayasu Y, Higuchi H, Ishii-Maruhama M, Yamane A, Yabuki A, Honda Y, Egusa M, Miyawaki T."
Independent factors affecting recovery time after sedation in patients with intellectual disabilities.
Open Dent J ", " 9 146-149 ", " 2015

65) "Maeda S, Tomoyasu Y, Higuchi H, Ishii-Maruhama M, Egusa M, Miyawaki T."
Independent predictors of delay in emergence from general anesthesia.
Anesth Prog ", " 62 8-13 ", " 2015

66) "Yamane A, Higuchi H, Tomoyasu Y, Ishii-Maruhama M, Maeda S, Miyawaki T."
Effect of dexmedetomidine injected into the oral mucosa in combination with lidocaine on local anesthetic potency in humans: a crossover double-blind study.
J Oral Maxillofac Surg ", " 73 616-621 ", " 2015

67) "Watanabe Y, Higuchi H, Ishii-Maruhama M, Honda Y, Yabuki-Kawase A, Yamane-Hirano A, Tomoyasu Y, Maeda S, MiyazakiT "
"Effect of low-dose midazolam on high blood pressure in dental patients: a randomized, double-blind, placebo-controlled, multi center study"
Br J Oral Maxillofac Surg. ", " in press ", " 2015

68) "Hayashi T, Higuchi H, Tomoyasu Y, Ishii-Maruhama M, Maeda S, Miyawaki T."
Effect of carbamazepine or phenytoin therapy on blood level of intravenously administered midazolam: a prospective cohort study
J Anesth. ", " in press ", " 2015

69) "Shigeru Maeda, Yumiko Tomoyasu, , Hitoshi Higuchi, Minako Ishii-Maruhama, Ayaka Yamane, Akiko Yabuki, Yuka Honda, Masahiko Egusa, Takuya Miyawaki"
Independent factors affecting recovery time after sedation in patients with intellectual disabilities.
Open Dent J ", " 31 146-149 ", " 2015

70) "Yuka Honda, Hitoshi Higuchi, Yoshikazu Matsuoka, Akiko Yabuki-Kawase, Minako Ishii-Maruhama, Yumiko Tomoyasu, Shigeru Maeda, Hiroshi Morimatsu, Takuya Miyawaki"
The inhibitory effect of locally injected dexmedetomidine on carrageenan-induced nociception in rats.
Eur J Pharmacol ", " 764 215-219 ", " 2015

71) "Taguchi Y, Sato K, Yukitake H, Inoue T, Nakayama M, Naito M, Kondo Y, Kano K, Hoshino T, Nakayama K,?Takashiba S, Ohara N."
"Involvement of an Skp-Like Protein, PGN_0300, in the Type IX Secretion System of Porphyromonas gingivalis."
Infect Immun ", " 84 230-240 ", " 2015

72) "Takeuchi-Hatanaka K, Yasuda T, Naruishi K, Katsuragi-Fuke K, Inubushi J, Ootsuki H, Maeda H, Takashiba S "
"Effects of new over-the-counter periodontal ointment-containing applicator with single-tuft brush on cytokine levels in gingival crevicular fluid during supportive periodontal therapy phase: a randomized double-blind clinical trial. "
J Periodontal Res ", " 51 321-331 ", " 2015

73) "Takashima Y, Fujita K, Ardin AC, Nagayama K, Nomura R, Nakano K, Matsumoto-Nakano M."
Characterization of the dextran-binding domain in the glucan-binding protein C of Streptococcus mutans.
Journl of Applied Microbiology ", " doi: 10.1111/jam.12895. ", " 2015

74) "Lapirattanakul J, Nomura R, Matsumoto-Nakano M, Srisatjaluk R, Ooshima T, Nakano K."
Variation of expression defects in cell surface 190-kDa protein antigen of Streptococcus mutans.
International Medical Microbiology ", " 305 383-391 ", " 2015

75) "Matsumi Y, Fujita K, Takashima Y, Yanagida K, Morikawa Y, Matsumoto-Nakano M."
Contribution of glucan-binding protein A to firm and stable biofilm formation by Streptococcus mutans.
Molecular Oral Micorbiology ", " 30 217-226- ", " 2015

76) "Shirai M, Nomura R, Kato Y, Murakami M, Kondo C, Takahashi S, Yamasaki Y, Matsumoto-Nakano M, Arai N, Yasuda H, Nakano K, Asai F."
Short communication: Distribution of Porphyromonas gulae fimA genotypes in oral specimens from dogs with mitral regurgitation
Research in Veterinary Science ", " 102 49-52 ", " 2015

77) "Matsumi Y, Fujita K, Takashima Y, Yanagida K, Morikawa Y, Matsumoto-Nakano M"
Contribution of glucan-binding protein A to firm and stable biofilm formation by Streptococcus mutans.
Mol Oral Microbiol ", " 30 217-226 ", " 2015

78) "Lapirattanakul J, Nomura R, Matsumoto-Nakano M, Srisatjaluk R, Ooshima T, Nakano K"
Variation of expression defects in cell surface 190-kDa protein antigen of Streptococcus mutans.
Int J Med Microbiol ", " 305 :383-391 ", " 2015

79) "Takashima Y, Fujita K, Ardin AC, Nagayama K, Nomura R, Nakano K, Matsumoto-Nakano M"
Characterization of the dextran-binding domain in the glucan-binding protein C of Streptococcus mutans.
J Appl Microbiol ", " Jul 14. doi: 10.1111/jam.12895. [Epub ahead of print] ", " 2015

80) 柳田可奈子
Streptococcus mutanに影響を与える形態決定遺伝子の機能分析    
岡山歯学会雑誌 ", " 34 1-13 ", " 2015

81) 枝広あや子,渡邊 裕,平野浩彦,古屋純一,中島純子,田村文誉,北川 昇,堀 一浩,原 哲也,吉川峰加,西 恭宏,永尾 寛,服部佳功,市川哲雄,櫻井 薫
認知症患者の歯科的対応および歯科治療のあり方―学会の立場表明 2015―
老年歯科医学 ", " 3-11 ", " 2015

82) "Yamane A, Higuchi H, Tomoyasu Y, Ishii-Maruhama M, Maeda S, Miyawaki T:"
Effect of dexmedetomidine injected into the oral mucosa in combination with lidocaine on local anesthetic potency in humans: A crossover double-blind study
J Oral Maxillofac Surg ", " 73 616-621 ", " 2015

83) "Honda Y, Higuchi H, Matsuoka Y, Yabuki-Kawase A, Ishii-Maruhama M, Tomoyasu Y, Maeda S, Morimatsu H, Miyawaki T"
The inhibitory effect of locally injected dexmedetomidine on carrageenan-induced nociception in rats
Eur J Pharmacol ", " 764 215-219 ", " 2015

84) "Takeuchi-Hatanaka K, Yasuda T, Naruishi K, Katsuragi-Fuke K, Inubushi J, Ootsuki H, Maeda H, Takashiba S "
"Effects of new over-the-counter periodontal ointment-containing applicator with single-tuft brush on cytokine levels in gingival crevicular fluid during supportive periodontal therapy phase: a randomized double-blind clinical trial. "
", " ", " 2015

85) "Mizutani S, Ekuni D, Tomofuji T, Irie K, Azuma T, Iwasaki Y, Morita M."
Self-efficacy and progression of periodontal disease: a prospective cohort study.
J Clin Periodontol. ", " 42 1083-1089 ", " 2015

86) "Machida T, Tomofuji T, Ekuni D, Maruyama T, Yoneda T, Kawabata Y, Mizuno H, Miyai H, Kunitomo M, Morita M."
"MicroRNAs in Salivary Exosome as Potential Biomarkers of Aging. "
Int J Mol Sci. ", " 16 21294-309 ", " 2015

87) "Takeuchi N, Ekuni D, Tomofuji T, Morita M. "
"Relationship between Acute Phase of Chronic Periodontitis and Meteorological Factors in the Maintenance Phase of Periodontal Treatment: A Pilot Study. "
Int J Environ Res Public Health. ", " 12 9119-30 ", " 2015

88) "Kawabata Y, Ekuni D, Miyai H, Kataoka K, Yamane M, Mizutani S, Irie K, Azuma T, Tomofuji T, Iwasaki Y, Morita M."
"Relationship Between Prehypertension/Hypertension and Periodontal Disease: A Prospective Cohort Study. "
Am J Hypertens. ", " 29 388-396 ", " 2015

89) "Kuroi R, Minakuchi H, Hara ES, Kawakami A, Maekawa K, Okada H, Kuboki T."
A risk factor analysis of accumulated postoperative pain and swelling sensation after dental implant surgery using a cellular phone-based real-time assessment.
J Prosthodont Res ", " 59 194-198 ", " 2015

90) 千神八重子,佐々木禎子,池田尚子,高坂由紀奈,三浦留美,菅 梓,水口 一
大学病院保存科・補綴科外来での歯科衛生実地指導の実態ならびに受診患者の満足度に関与する因子の解明
日本歯科衛生学会雑誌 ", " 10 50-58 ", " 2015

91) "菊谷 武,吉田光由,菅 武雄,木村年秀,田村文誉,窪木拓男"
歯の喪失ならびに口腔機能低下が栄養状態に及ぼす影響-アセスメント法の開発-
日本歯科医学会誌 ", " 34 59-63 ", " 2015

92) "吉田登志子,山中玲子,菅原康代,伊原木聰一郎,村上 隆,村田尚道,志茂 剛,柳田剛志,縄稚久美子,星加知宏"
早期見学実習の一環として実施した振り返りを取り入れたエスコート実習の評価-過去8年間の検討-
日本歯科医学教育学会雑誌 ", " 31 16-24 ", " 2015

93) "Matsuo R, Kobashi M, Mitoh Y, Fujita M"
Role of the lteral hypothalamus in submandibular salivary section during feeding in rats.
Brain Research ", " 1596 99-107 ", " 2015

2014

1) "Aya Maeda-Uematsu, Satoshi Kubota, Harumi Kawaki, Kazumi Kawata, Yoshiaki Miyake, Takako Hattori, Takashi Nishida, Norifumi Moritani, Karen M. Lyons, Seiji Iida and Masaharu Takigawa"
CCN2 as a novel molecule that supports energy metabolism of chondrocytes.
J. Cell Biochem. ", " 115 854-865 ", " 2014

2) "Kondo S, Mukudai Y, Soga D, Nishida T, Takigawa M, Shirota T"
Differential expression of vascular endothelial growth factor in high- and low- metastasis cell lines of salivary gland adenoid cystic carcinoma.
Anticancer Res. ", " 34 671-7. ", " 2014

3) 三島弘幸、門田理佳、尾碕真帆、服部淳彦、鈴木信雄、筧(かけい)光男、松本敬、池亀美華、見明康雄:
メラトニン投与による象牙質の組成や組織構造の変化に関する分析学的及び組織学的研究
日本再生歯科医学会誌  ", " 12 11-22 ", " 2014

4) "Akiyoshi YAMAGAMI, Noriyuki NAGAOKA, Kumiko YOSHIHARA, Mariko NAKAMURA, Hajime SHIRAI, Takuya MATSUMOTO, Kazuomi SUZUKI, and Yasuhiro YOSHIDA"
Ultra-structural evaluation of an anodic oxidated titanium dental implant
Dental Materials Journal ", " 33 828-834 ", " 2014

5) " Yoneda T, Tomofuji T, Kawabata Y, Ekuni D, Azuma T, Kataoka K, Kunitomo M, Morita M. "
Application of coenzyme Q10 for accelerating soft tissue wound healing after tooth extraction in rats.
Nutrients Nutrients. ", " 106 5756-69. ", " 2014

6) "Nomura R, Otsugu M, Naka S, Teramoto N, Kojima A, Muranaka Y, Matsumoto-Nakano M, Ooshima T, Nakano K. "
Contribution of the interaction of Streptococcus mutans serotype k strains with fibrinogen to the pathogenicity of infective endocarditis.
Infect Immun. ", " 82 5223-34. ", " 2014

7) "Yukinori Maruo, Goro Nishigawa Masao Irie, Kuniko Yoshihara, Shogo Minagi. "
"Flexural properties of polyethylene, glass and carbon fiber-reinforced resin composites for prosthetic frameworks. "
"Acta Odontogica Scandinavica," ", " 73 581-587 ", " 2014

8) "Tagawa J, Inoue T, Naito M, Sato K, Kuwahara T, Nakayama M, Nakayama K, Yamashiro T, Ohara N"
Development of a novel plasmid vector pTIO-1 adapted for electrotransformation of Porphyromonas gingivalis
J Microbiol Method ", " 105 174-179 ", " 2014

9) "Mandai H, Omori K, Yamamoto D, Tsumura T, Murota K, Yamamoto S, Mitsudo K, Ibaragi S, Sasaki A, Maeda H, Takashiba S, Suga S. "
Synthetic (+)-terrein suppresses interleukin-6/soluble interleukin-6 receptor induced-secretion of vascular endothelial growth factor in human gingival fibroblasts.
Bioorg Med Chem. ", " 22 5338-44.? ", " 2014

10) "Takabatake K, Yamachika E, Tsujigiwa H, Takeda Y, Kimura M, Takagi S, Nagatsuka H, Iida S."
Effect of geometry and microstructure of honeycomb TCP scaffolds on bone regeneration.
J Biomed Mater Res A. ", " 102 2952-60. ", " 2014

11) "Ardin AC, Fujita K, Nagayama K, Takashima Y, Nomura R, Nakano K, Ooshima T, Matsumoto-Nakano M. "
Identification and Functional Analysis of an Ammonium Transporter in Streptococcus mutans.
PLoS One. ", " 9 e107569 ", " 2014

12) "Charrier A, Chen R, Chen L, Kemper S, Hattori T, Takigawa M, Brigstock DR."
" Exosomes mediate intercellular transfer of pro-fibrogenic connective tissue growth factor (CCN2) between hepatic stellate cells, the principal fibrotic cells in the liver. "
Surgery. ", " 156 548-55 ", " 2014

13) "Masao Irie, Jiro Tanaka, Yukinori Maruo, Goro Nishigawa. "
Vertical and Horizontal Polymerization Shrinkages in Composite Restorations.
Dental Materials ", " 30 e189-e198 ", " 2014

14) "Nagayama K, Fujita K, Takashima Y, Ardin AC, Ooshima T, Matsumoto-Nakano M.:"
Role of ABC transporter proteins in stress responses of Streptococcus mutans.
Oral Health Dent Manag. ", " 13 359-65. ", " 2014

15) "Abd El Kader T1, Kubota S, Anno K, Tanaka S, Nishida T, Furumatsu T, Aoyama E, Kuboki T, Takigawa M."
Direct interaction between CCN family protein 2 and fibroblast growth factor 1.
J Cell Commun Signal. ", " 8 157-63. ", " 2014

16) "Charrier A, Chen R, Chen L, Kemper S, Hattori T, Takigawa M, Brigstock DR."
Connective tissue growth factor (CCN2) and microRNA-21 are components of a positive feedback loop in pancreatic stellate cells (PSC) during chronic pancreatitis and are exported in PSC-derived exosomes.
J Cell Commun Signal. ", " 8 147-156 ", " 2014

17) "Masao Irie, Ikuko Nishida, Kenshi Maki. "
Class I Gap-formation in Various Glass-ionomer Restorations Minimized by Delayed Polishing.
日本外傷歯学会雑誌. ", " 10 37-43 ", " 2014

18) "Perbal B, Trackman P, Castellot J, Brigstock D, Takigawa M, Lau L, Leask A."
Report on the 7(th) international workshop on the CCN family of genes
J Cell Commun Signal. ", " 8 ", " 2014

19) Kubota S. and Takigawa M.
Cellular and molecular actions of CCN2/CTGF and their role under physiological and pathological conditions.
Clinical Science ", " 128 181-96 ", " 2014

20) "Abd El Kader, T., Kubota, S., Nishida, T., Hattori, T., Aoyama E., Janune, D., Hara, E. S., Ono, M., Tabata, Y., Kuboki, T. and Takigawa, M."
The regenerative effects of CCN2 independent modules on chondrocytes in vitro and osteoarthritis models in vivo.
Bone ", " 59 180-188 ", " 2014

21) "Hiromi Kumon, Eiji Matsuura, Noriyuki Nagaoka, Toshio Yamamoto, Shinya Uehara, Motoo Araki, Yukana Matsunami, Kazuko Kobayashi, Akira Matsumoto"
Ectopic calcification: importance of common nanoparticle scaffolds containing oxidized acidic lipids
Nanomedicine ", " 10 441-450 ", " 2014

22) "K. Yoshihara, Y. Yoshida, S. Hayakawa, N. Nagaoka, S. Kamenoue, T. Okihara, T. Ogawa, M. Nakamura, A. Osaka and B. Van Meerbeek"
Novel Fluoro-carbon Functional Monomer for Dental Bonding
Journal of Dental Research ", " 93 189-194 ", " 2014

23) "Fujita H., Yamamoto M., Ogino T., Kobuchi H., Ohmoto N., Aoyama E., Oka T., Nakanishi T., Inoue K., Sasaki J."
Necrotic and apoptotic cells serve as nuclei for calcification on osteoblastic differentiation of human mesenchymal stem cells in vitro.
Cell Biochem Funct ", " 32 77-86 ", " 2014

24) "Inoue T, Nakayama M, Taguchi Y, Kano K, Ono M, Shimizu Y, Kuroda T, Ohara N"
Characterization of the tripartite drug efflux pumps of Porphyromonas gingivalis ATCC 33277
New Microbiol ", " 38 101-108 ", " 2014

25) "Tsuyoshi Shimo*, Eiki Koyama, Yuu Horikiri, Tatsuo Okui, Naito Kurio, Naoki Katase, Shoko Yoshida , Yuichiro Takebe, Koji Kishimoto, Norie Yoshioka, Hitoshi Nagatsuka, Akira Sasaki."
Expression and roles of CCN2 in dental mesenchymal cells in primary culture ? with findings in a case of odontogenic myxofibroma
Oral Science International ", " 118-14 ", " 2014

26) "Fujita Y, Nakayama M, Naito M, Yamachika E, Inoue T, Nakayama K, Iida S, Ohara N"
Hemoglobin receptor protein from Porphyromonas gingivalis induces interleukin-8 production in human gingival epithelial cells through stimulation of the mitogen-activated protein kinase and NF-κB signal transduction pathways
Infect Immun 2014 ", " 82 202-211 ", " 2014

27) "Shinga-Ishihara C, Nakai Y, Milgrom P, Murakami K, Matsumoto-Nakano M. "
Cross-cultural validity of a dietary questionnaire for studies of dental caries risk in Japanese.
BMC Oral Health. ", " 214 ", " 2014

28) "Fujita Y, Nakayama M, Naito M, Yamachika E, Inoue T, Nakayama K, Iida S, Ohara N."
Hemoglobin receptor protein from Porphyromonas gingivalis induces interleukin-8 production in human gingival epithelial cells through stimulation of the mitogen-activated protein kinase and NF-κB signal transduction pathways.
Infect Immun. ", " 82 202-11. ", " 2014

29) "Yi Shang, Miho Tamai, Ryusei Ishii, Noriyuki Nagaoka, Yasuhiro Yoshida, Masamichi Ogasawara, Jun Yang, Yoh-ichi Tagawa"
Hybrid sponge comprised of galactosylated chitosan and hyaluronic acid mediates the co-culture of hepatocytes and endothelial cells
Journal of Bioscience and Bioengineering ", " 117 99-106 ", " 2014

30) 入江正郎,田仲持郎,松本卓也,丸尾幸憲,西川悟郎,吉山昌宏
コンポジットレジン修復の歯質接着強さの経時的推移
 接着歯学 ", " 32 8-13 ", " 2014

31) " Zaman F, Chrysis D, Huntjens K, Chagin A, Takigawa M, Fadeel B, S?vendahl L."
Dexamethasone differentially regulates Bcl-2 family proteins in human proliferative chondrocytes:Role of pro-apoptotic Bid.
Toxicol Lett. ", " ?224 196-200. ", " 2014

32) "Chen C, Akiyama K, Yamaza T, You YO, Xu X, Li B, Zhao Y, Shi S."
Telomerase governs immunomodulatory properties of mesenchymal stem cells by regulating FAS ligand expression.
"EMBO Molecular Medicine," ", " 6 322-334 ", " 2014

33) "Ono M, Sonoyama W, Yamamoto K, Oida Y, Akiyama K, Shinkawa S, Nakajima R, Pham HT, Hara ES, Kuboki T."
Efficient bone formation in a swine socket lift model using Escherichia coli-derived recombinant human bone morphogenetic protein-2 adsorbed in β-tricalcium phosphate.
Cells Tissues Organs ", " 199 249-255 ", " 2014

34) "Moshaverinia A, Chen C, Xu X, Akiyama K, Ansari S, Zadeh HH, Shi S."
Bone regeneration potential of stem cells derived from periodontal ligament or gingival tissue sources encapsulated in RGD-modified alginate scaffold.
Tissue Eng Part A. ", " 20 611-621 ", " 2014

35) "Yamaguchi D, Terayama R, Omura S, Tsuchiya H, Sato T, Ichikawa H, Sugimoto T"
Effect of adenosine A1 receptor agonist on the enhanced excitability of spinal dorsal horn neurons after peripheral nerve injury.
Int J Neurosci ", " 124 213-222 ", " 2014

36) "Terayama R, Maruhama K, Tsuchiya H, Mizutani M, Iida S, Sugimoto T"
Assessment of intraoral mucosal pain induced by the application of capsaicin.
Arch Oral Biol ", " 59 1334-1341 ", " 2014

37) "Mino T, Maekawa K, Ueda A, Higuchi S, Sejima J, Takeuchi T, Hara ES, Kimura-Ono A, Sonoyama W, Kuboki T"
In silico comparison of the reproducibility of full-arch implant provisional restorations to final restoration between a 3D Scan/CAD/CAM technique and the conventional method.
Journal of Prosthodontic Research. ", " 59 152-158 ", " 2014

38) 水口真実,前川賢治,菊谷 武,田村文誉,吉田光由,大野友久,玉田泰嗣,近藤尚知,木本克彦,大川周治,佐藤裕二,鈴木浩司,川良美佐雄,窪木拓男
患者のステージに応じた摂食・咀嚼・嚥下評価法とその対応方法に関する研究
日本歯科医学会誌 ", " 34 94-98 ", " 2014

39) "Iida S, Hara T, Araki D, Ishimine-Kuroda C, Kurozumi A, Sakamoto S, Miyazaki T, Minagi S."
Memory-related gene expression profile of the male rat hippocampus induced by teeth extraction and occlusal support recovery
Arch Oral Biol ", " 59 133-41 ", " 2014

40) "Sanagawa T, Hara T, Minagi S."
A new quantitative screening method for removable prosthesis using pressure-indicating paste.
J Oral Rehabil. ", " 737-43 ", " 2014

41) "Sakamoto S, Hara T, Kurozumi A, Oka M, Kuroda-Ishimine C, Araki D, Iida S, Minagi S."
Effect of occlusal rehabilitation on spatial memory and hippocampal neurons after long-term loss of molars in rats.
J Oral Rehabil. ", " 715-22 ", " 2014

42) "Sukegawa S, Higuchi H, Inoue M, Nagatsuka H, Maeda S, Miyawaki T"
Locally injected dexmedetomidine inhibits carrageenin-induced inflammatory responces in the injected region.
Anesth Analg ", " 118 473-480 ", " 2014

43) "Yabuki A, Higuchi H, Yoshitomi T, Tomoyasu Y, Ishii-Maruhama M, Maeda S, Miyawaki T"
Locally injected dexmedetomidine induces vasoconstriction via peripheral α-2A adrenoceptor subtype in Guinea pigs
Reg Anesth Pain Med ", " 39 133-136 ", " 2014

44) "Higuchi H, Yabuki A, Ishii-Maruhama M, Tomoyasu Y, Maeda S, Miyawaki T"
Hemodynamic changes by drug interaction of adrenaline with chlorpromazine
Anesth Prog ", " 61 150-154 ", " 2014

45) 住吉由季子、森 貴幸、前川享子、村田尚道、野島靖子、小林幸生、後藤拓朗、神田ゆう子、田尻絢子、細坪充裕、馬場拓朗、江草正彦、宮脇卓也
大学病院スペシャルニーズ歯科におけるインシデント発生状況と転倒・転落事故防止への取り組みに関する報告
障害者歯科 ", " 35 180-187 ", " 2014

Biodental Research Center (April 1999 - May 2013)

Edited Book

1) Perbal, A., Takigawa, M. and Perbal, B.: CCN Proteins in Health and Disease. Springer, Dordrecht, Nertherlands, pp.1-338, 2010.

2) Perbal, B. and Takigawa, M.: CCN Proteins : A New Family of Cell Growth and Differentiation Regulators. Imperial College Press, London, pp. 1-311, 2005.

Book Chapters

1) Kubota, S. and Takigawa, M.: CCN. Encyclopedia of Signaling Molecules (Choi S. ed.), Springer, pp. 273-281, 2012.

2) Eguchi, E., Kubota, S., Kawata, K., Mukudai Y., Uehara, J., Ohgawara, T., Ibaragi S., Sasaki, A., Kuboki, T. and Takigawa M.: Novel transcriptional regulation of CCN2/CTGF by nuclear translocation of MMP3. CCN Proteins in Health and Disease (Perbal, A., Takigawa, M. and Perbal, B. eds.), Springer, Dordrecht, Nertherlands, pp. 255-264, 2010.

3) Takigawa, M., Kawaki, H., Kubota, S., Lyons, K.M., Perbal B.: Cooperative regulation of cell proliferation and differentiation by CCN2 and CCN3. CCN Proteins in Health and Disease (Perbal, A., Takigawa, M. and Perbal, B. eds.), Springer, Dordrecht,  Nertherlands, pp. 105-109, 2010.

4) Kubota, S., Mukudai, Y., Kawaki, H., Kondo, S., Eguchi, T., Sumiyoshi, K., Ohgawara, T., Shimo, T. and Takigawa, M.: Nucleophosmin/B23: A multifunctional regulator that determines the fate of CCN2 m RNA. CCN Proteins in Health and Disease (Perbal, A., Takigawa, M. and Perbal, B. eds.), Springer, Dordrecht, , Nertherlands, pp. 41-55, 2010.

5) Takigawa M: CTGF/Hcs24/CCN2 as a regeneration factor ("regenerin") acting on various types of mesenchymal cells. Progress in Stem Cell Research (Columbus F, ed) , Nova Science, Hauppauge, NY, pp. 101-128, 2005.

6) Takigawa, M., Nishida, T., Kubota, S.: Roles of CCN2/CTGF in the control of growth and regeneration. In CCN Proteins: A New Family of Cell Growth and Differentiation Regulators (Perbal B. & Takigawa M. eds.) Imperial College Press, London, pp. 19-59, 2005.

7) Perbal, B. and Takigawa, M.: The CCN proteins - An Overview. In CCN Proteins: A New Family of Cell Growth and Differentiation Regulators (Perbal B. & Takigawa M. eds.) Imperial College Press, London, pp. 1-18, 2005.

8) Kubota S and Takigawa M: Driving the driver: Molecular regulation of ctgf/HCS24/ccn2 that regulates chondrocyte growth and differentiation. Recent Res. Develop. Biophys. Biochem. 3 (part 2), pp. 996-1012, 2003.

9) Takigawa,M.: Physiological roles of connective tissue growth factor (CTGF/Hcs24): promotion of endochondral ossification, angiogenesis and tissue remodeling, In Tissue Engineering for Therapeutic Use (ed, Shimizu, Y.). Vol.4., Elsevier, Amsterdam, 1-13, 2000.

Review Articles

1) Kubota, S., Takigawa, M.: The role of CCN2 in cartilage and bone development. J. Cell Commun. Signal., 5, 209-2017, 2011 (invited review)

2) Kubota, S. and Takigawa, M. Role of CCN2/CTGF/Hcs24 in Bone Growth. Int. Rev Cytol. (invited review) 257, 1-41, 2007 (invited review)

4) Kubota, S. and Takigawa, M. CCN family proteins and angiogenesis: from embryo to adulthood. Angiogenesis (invited review). 10(1): 1-11, 2007.

5) Brigstock DR, Goldshemeding R, Katsube KI, Lam SC, Lau LF, Lyons K, Naus C, Perbal B Riser B, Takigawa M and Yeger H.: Proposal for a unified CCN nomenclature. Mol Pathol. 56, 127-128, 2003.

6) Takigawa M.: CTGF/Hcs 24 as a multifunctional growth factor for fibroblasts, chondrocytes, and vascular endothelial cells. Drug News Perspect.(invited review), 16, 11-21, 2003.

7) Takigawa, M., Nakanishi, T., Kubota, S. and Nishida, T.: The role of CTGF/Hcs24/ecogenin in skeletal growth control. J. Cell. Physiol., (invited review) 194, 256-266, 2003.

Molecular Databases

1) Kubota, S. and M. Takigawa. 2007. CTGF(connective tissue growth factor). Atlas of Genetics and Cytogenetics in Oncology and Haematology. URL: http://atlasgeneticsoncology.org/

2) Kubota, S. and M. Takigawa. 2007. CCN2. UCSD/Nature Molecule Page, The Signaling Gateway. doi.10.1038/mp.a003961.01URL: http://www.signaling-gateway.org/molecule/query?afcsid=A003961.

Peer-Reviewed Original Articles

1) Murata H, Hattori T, Maeda H, Takashiba S, Takigawa M, Kido J, Nagata T.: Identification of transactivation-responsive DNA-binding protein 43 (TARDBP43; TDP-43) as a novel factor for TNF-α expression upon lipopolysaccharide stimulation in human monocytes. J. Periodontal Res. 2014 Sep 9. doi: 10.1111/jre.12227. [Epub ahead of print] 2) Nishida T, Kubota S, Aoyama E, Janune D, Lyons KM, Takigawa M: CCN family protein 2 (CCN2) promotes the early differentiation, but inhibits the terminal differentiation of skeletal myoblasts. J. Biochem., in press. 3) Abd El Kader T, Kubota S, Anno K, Tanaka S, Nishida T, Furumatsu T, Aoyama E, Kuboki T, Takigawa M. Direct interaction between CCN family protein 2 and fibroblast growth factor 1. J. Cell Commun. Signal. 8(2):157-63, 2014. 4) Charrier A, Chen R, Chen L, Kemper S, Hattori T, Takigawa M, Brigstock DR.: Exosomes mediate intercellular transfer of pro-fibrogenic connective tissue growth factor (CCN2) between hepatic stellate cells, the principal fibrotic cells in the liver. Surgery. 156, 548-55, 2014 5) Charrier A, Chen R, Chen L, Kemper S, Hattori T, Takigawa M, Brigstock DR.: Connective tissue growth factor (CCN2) and microRNA-21 are components of a positive feedback loop in pancreatic stellate cells (PSC) during chronic pancreatitis and are exported in PSC-derived exosomes. J Cell Commun Signal. 8, 147-156, 2014. 6) Kondo S, Mukudai Y, Soga D, Nishida T, Takigawa M, Shirota T: Differential expression of vascular endothelial growth factor in high- and low- metastasis cell lines of salivary gland adenoid cystic carcinoma. Anticancer Res. 34(2):671-7, 2014 7) Aya Maeda-Uematsu, Satoshi Kubota, Harumi Kawaki, Kazumi Kawata, Yoshiaki Miyake, Takako Hattori, Takashi Nishida, Norifumi Moritani, Karen M. Lyons, Seiji Iida and Masaharu Takigawa: CCN2 as a novel molecule that supports energy metabolism of chondrocytes. J. Cell Biochem. 115, 854-865, 2014. 8) Tarek Abd El Kadera, Satoshi Kubotaa, Takashi Nishida, Takako Hattori, Eriko Aoyama, Danilo Janune, Emilio S. Hara, Mitsuaki Ono, Yasuhiko Tabata, Takuo Kuboki, Masaharu Takigawa: The regenerative effects of CCN2 independent modules on chondrocytes in vitro and osteoarthritis models in vivo. Bone, 59:180-8, 2014. 9) Zaman F, Chrysis D, Huntjens K, Chagin A, Takigawa M, Fadeel B, S?vendahl L.: Dexamethasone differentially regulates Bcl-2 family proteins in human proliferative chondrocytes: role of pro-apoptotic Bid. Toxicol Lett. 2014 Jan 13;224(2):196-200. 10) Ultra-structural evaluation of an anodic oxidated titanium dental implant; A. Yamagami, N. Nagaoka, K. Yoshihara, M. Nakamura, H. Shirai, T. Matsumoto, K. Suzuki, Y. Yoshida, Dental Materials Journal, in press, 2014 11) Ectopic calcification: importance of common nanoparticle scaffolds containing oxidized acidic lipids; H. Kumon, E. Matsuura, N. Nagaoka, T. Yamamoto, S. Uehara, M. Araki, Y. Matsunami, K. Kobayashi, A. Matsumoto, Nanomedicine, 10, 441-450, 2014 12) Novel Fluoro-carbon Functional Monomer for Dental Bonding; K. Yoshihara, Y. Yoshida, S. Hayakawa, N. Nagaoka, S. Kamenoue, T. Okihara, T. Ogawa, M. Nakamura, A. Osaka, B. Van Meerbeek; Journal of Dental Research, 93, 189-194, 2014 13) Hybrid sponge comprised of galactosylated chitosan and hyaluronic acid mediates the co-culture of heaptocytes and endothelial cells; Y. Shang, M. Tamai, R. Ishii, N. Nagaoka, Y. Yoshida, M. Ogasawara, J. Yang, Y. Tagawa, Journal of Bioscience and Bioengineering, 117, 99-106, 2014 14) Inoue T, Nakayama M, Taguchi Y, Kano K, Ono M, Shimizu Y, Kuroda T, Ohara N. Characterization of the tripartite drug efflux pumps of Porphyromonas gingivalis ATCC 33277. New Microbiologica. 2014, in press. 15) Tagawa J, Inoue T, Naito M, Sato K, Kuwahara T, Nakayama M, Nakayama K, Yamashiro T, Ohara N. Development of a novel plasmid vector pTIO-1 adapted for electrotransformation of Porphyromonas gingivalis. J Microbiol Method. 2014; 105: 174-179. 16) Fujita Y, Nakayama M, Naito M, Yamachika E, Inoue T, Nakayama K, Iida S, Ohara N. Hemoglobin receptor protein from Porphyromonas gingivalis induces interleukin-8 production in human gingival epithelial cells through stimulation of the mitogen-activated protein kinase and NF-κB signal transduction pathways. Infect Immun. 2014; 82: 202-211. 17) Nishida T, Kubota S, Aoyama E, Takigawa M: Impaired glycolytic metabolism causes chondrocyte hypertrophy-like changes via promotion of phospho-Smad1/5/8 translocation into nucleus. Osteoarthritis Cartilage, 21(5):700-9. 2013. 18) Tomita N, Hattori T, Ito, S, Aoyama E, Yao M, Yamashiro T and Takigawa M: Cartilage-specific overexpression of CCN family member 2/connective tissue growth factor (CCN2/CTGF) stimulates insulin-like growth factor expression and bone growth. Plos One, 8(3):e59226, 2013. 19) Adhesive interfacial interaction affected by different carbon-chain monomers; K. Yoshihara, Y. Yoshida, N. Nagaoka, S. Hayakawa, T. Okihara, J. De Munck, Y. Maruo, G. Nishigawa, S. Minagi, A. Osaka, B. Van Meerbeek, Dental Materials, 29, 888-897, 2013 20) A red-emissive aminobenzopyrano-xanthene dye: elucidation of fluorescence emission mechanisms in solution and in the aggregate state; S. Kamino, A. Muranaka, M. Murakami, A. Tatsumi, N. Nagaoka, Y. Shirasaki, K. Watanabe, K. Yoshida, J. Horigome, S. Komeda, M. Uchiyama, S. Enomoto, Physical Chemistry Chemical Physics, 15, 2131-2140, 2013 21) Aoyama E, Kubota S, Takigawa M. CCN2/CTGF binds to fibroblast growth factor receptor 2 and modulates its signaling. FEBS Lett, 586 4270-5, 2012. 22) Hara ES, Ono M, Kubota S, Sonoyama W, Oida Y, Hattori T, Nishida T, Furumatsu T, Ozaki T, Takigawa M, Kuboki T. Novel chondrogenic and chondroprotective effects of the natural compound harmine. Biochimie, 95 374-381, 2012. 23) Abd El Kader T, Kubota S, Janune D, Nishida T, Hattori T, Aoyama E, Perbal B, Kuboki T, Takigawa M. Anti-fibrotic effect of CCN3 accompanied by altered gene expression profile of the CCN family. J Cell Commun Signal, 7, 11-18, 2013 24) Adhesive interfacial interaction affected by different carbon-chain monomers; K. Yoshihara, Y. Yoshida, N. Nagaoka, S. Hayakawa, T. Okihara, J. De Munck, Y. Maruo, G. Nishigawa, S. Minagi, A. Osaka, B. Van Meerbeek, Dental Materials, 29, 888-897, 2013 25) A red-emissive aminobenzopyrano-xanthene dye: elucidation of fluorescence emission mechanisms in solution and in the aggregate state; S. Kamino, A. Muranaka, M. Murakami, A. Tatsumi, N. Nagaoka, Y. Shirasaki, K. Watanabe, K. Yoshida, J. Horigome, S. Komeda, M. Uchiyama, S. Enomoto, Physical Chemistry Chemical Physics, 15, 2131-2140, 2013 26) Takemura-Uchiyama, I, Uchiyama J, Kato S-I, Inoue T, Ujihara T, Ohara N, Daibata M, Matsuzaki S. Evaluating efficacy of bacteriophage therapy against Staphylococcus aureus infections using a silkworm larval infection model. FEMS Microbiol Lett. 2013, 347: 52-60. 27) Honjo T, Kubota S, Kamioka H, Sugawara Y, Ishihara Y, Yamashiro T, Takigawa M, Takano-Yamamoto T. Promotion of Ccn2 expression and osteoblastic differentiation by actin polymerization, which is induced by laminar fluid flow stress. J Cell Commun Signal, 6(4), 225-232, 2012. 28) Hoshijima M, Hattori T, Aoyama E, Nishida T, Yamashiro T, Takigawa M. Roles of heterotypic CCN2/CTGF-CCN3/NOV and homotypic CCN2-CCN2interactions in expression of the differentiated phenotype of chondrocytes. FEBS J, 279(19), 3584-3597, 2012. 29) Furumatsu T, Kanazawa T, Miyake Y, Kubota S, Takigawa M, Ozaki T. Mechanical stretch increases Smad3-dependent CCN2 expression in inner meniscus cells. J Orthop Res. 30 1738-1745 2012. 30) Hattori Y, Kojima T, Kato D, Matsubara H, Takigawa M, Ishiguro N. A selective estrogen receptor modulator inhibits tumor necrosis factor-α-induced apoptosis through the ERK1/2 signaling pathway in human chondrocytes. Biochem Biophys Res Commun. 2012 May 11;421(3):418-24. Epub 2012 Mar 29. 31) Kawata K, Kubota S, Eguchi T, Aoyama E, Moritani NH, Kondo S, Nishida T, Takigawa M. Role of low-density lipoprotein receptor related protein 1 (LRP1) in CCN2/connective tissue growth factor (CTGF) protein transport in chondrocytes. J. Cell Sci., 125 2965-72, 2012. 32) HEMA Inhibits Interfacial Nano-layering of the Functional Monomer MDP; Y. Yoshida, K. Yoshihara, S. Hayakawa, N. Nagaoka, T. Okihara, T. Matsumoto, S. Minagi, A. Osaka, K. Van Landuyt and B. Van Meerbeek, Journal of Dental Research, 91, 1060-1065, 2012 33) X-ray diffraction analysis of three-dimensional self-reinforcing monomer and its chemical interaction with tooth and hydroxyapatite; Y. Yoshida, K. Yoshihara, N. Nagaoka, M. Hanabusa, T. Matsumoto, Y. Momoi, Dental Materials Journal, 31, 697-702, 2012 34) Osteoblast compatibility of materials depends on serum protein absorbability in osteogenesis; K. Harimoto, Y. Yoshida, K. Yoshihara, N. Nagaoka, T. Matsumoto, Y. Tagawa, Dental Materials Journal, 31, 674-680, 2012 35) Real time assessment of surface interactions with a titanium passivation layer by surface plasmon resonance; I. Hirata, Y. Yoshida, N. Nagaoka, K. Hiasa, Y. Abe, K. Maekawa, T. Kuboki, Y. Akagawa, K. Suzuki, B. Van Meerbeek, P. B. Messersmith, M. Okazakia, Acta biomaterialia, 8, 1260-1266, 2012 36) Self-assembled Nano-layering at the Adhesive Interface; Y. Yoshida, K. Yoshihara, N. Nagaoka, S. Hayakawa, Y. Torii, T. Ogawa, A. Osaka, B.Van Meerbeek, Journal of Dental Research, 91, 376-381, 2012 37) Nishida T, Kubota S, Aoyama E, Janune D, Maeda A, Takigawa M.: Effect of CCN2 on FGF2-Induced Proliferation and MMP9 and MMP13 Productions by Chondrocytes. Endocrinology, 152, 4232-41, 2011. 38) Janune, D., Kubota, S., Nishida, T., Kawaki, H., Perbal B, Iida S, Takigawa M.: Novel effects of CCN3 that may direct the differentiation of chondrocytes. FEBS Lett., 585 3033-40, 2011 39) Kawaki, H., Kubota, S., Suzuki, A., Suzuki, M., Kohsaka, K., Hoshi, K., Fujii, T., Lazer、N., Ohgawara, T., Maeda, T., Perbal, B., Takano-Yamamoto, T., Takigawa, M. Differential roles of CCN family proteins during osteoblast differentiation: Involvement of Smad and MAPK signaling pathways. Bone 49975-989 2011. 40) Miyake, Y., Furumatsu, T., Kubota, S., Kawata, K., Ozaki, T., and Takigawa, M.: Mechanical stretch increases CCN2/CTGF expression in anterior cruciate ligament-derived cells. Biochem. Biophys. Res. Commun. 409 247-252 2011. 41) Kodama, T., Takehara, T., Hikita, H., Shimizu, S., Shigekawa, M., Tsunematsu, H., Li, W., Miyagi, T., Hosui, A., Tatsumi, T., Ishida, H., Kanto, T., Hiramatsu, N., Kubota, S., Takigawa, M., Tomimaru, Y., Tomokuni, A., Nagano, H., Doki, Y., Mori, M., Hayashi, N.: Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice. J. Clin. Invest., 121 3343-3356 2011. 42) Nishida, T., Emura, K., Kubota, S., Lyons, K. M., Takigawa, M. CCN family 2/ connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein (DC-STAMP). J. Bone Miner. Res. 26, 351-363, 2011. 43) Janune D, Kubota S, Lazar N, Perbal B, Iida S, Takigawa M.: CCN3-mediated promotion of sulfated proteoglycan synthesis in rat chondrocytes from developing joint heads. J. Cell Commun. Signal., 5, 167-171, 2011. 44) Ohgawara T, Kubota S, Kawaki H, Kurio N, Abd El Kader T, Hoshijima M, Janune D, Shimo T, Perbal B, Sasaki A, Takigawa M. Association of the metastatic phenotype with CCN family members among breast and oral cancer cells. J. Cell Commun. Signal., 5 291-299 2011. 45) Kondo S, Kubota S, Mukudai Y, Nishida T, Yoshihama Y, Shirota T, Shintani S, Takigawa M. Binding of glyceraldehyde-3-phosphate dehydrogenase to the cic-acting element of structure-anchored repression in Ccn2 mRNA. Biochem. Biophys. Res. Commun., 405, 382-387, 2011. 46) Self-etch Monomer-Calcium Salt Deposition on Dentin; K. Yoshihara, Y. Yoshida, S. Hayakawa, N. Nagaoka, Y. Torii, A. Osaka, K. Suzuki, S. Minagi, B. Van Meerbeek, and K.L. Van Landuyt, Journal of Dental Research, 90, 602-606, 2011 47) Nano-layering of phosphoric-acid ester monomer at enamel and dentin; K. Yoshihara, Y. Yoshida, S. Hayakawa, N. Nagaoka, M. Irie, T. Ogawa, K. L. Van Landuyt, A. Osaka, K. Suzuki, S. Minagi, B. Van Meerbeek, Acta Biomaterialia, 7, 3187-3195, 2011 48) Synthesis and characterization of lithium manganese oxides with core-shell; Y. Li, Y. Makita, Z. Lin, S. Lin, N. Nagaoka, X. Yang, Solid State Ionics, 196, 34-40, 2011 49) Sumiyoshi K, Kubota S, Ohgawara T, Kawata K, Nishida T, Tsuyoshi Shimo T, Yamashiro T and Takigawa M. Identification of miR-1 as an miRNA that supports late-stage differentiation of growth cartilage cells.  Bicochem. Biophys. Res. Commun., 402 286-290, 2010. 50) Kawaki H, Kubota S, Aoyama E, Fujita N, Hanagata H, Miyauchi A, Nakai K, Takigawa M.:Design and utility of CCN2 anchor peptide aptamers. Biochimie. 2010 Aug;92(8):1010-5. Epub 2010 May 8. 51) Takeuchi H, Kubota S, Murakashi E, Zhou Y, Endo K, Ng PS, Takigawa M, Numabe Y.: Nicotine-induced CCN2: from smoking to periodontal fibrosis. J Dent Res., 89(1):34-9, 2010. 52) Mukudai Y, Kubota S, Eguchi T, Sumiyoshi K, Janune D, Kondo S, Shintani S, Takigawa M. A coading RNA segment that enhances the ribosomal revruitment of chicken Ccn1 mRNA. J Cell Biochem. 111, 1607-1618, 2010. 53) Lindahl E, Nyman U, Zaman F, Palmberg C, Cascante A, Shafqat J, Takigawa M, S?vendahl L, J?rnvall H, Joseph B.: Proinsulin C-peptide regulates ribosomal RNA expression. J Biol Chem. , 285(5):3462-9, 2010. 54) Sumiyoshi K, Kubota, S, Furuta, RA, Tasui K, Aoyama, E, Kawaki H, Kawata, K, Ohgawara T, Yamashiro T, Takigawa M. Thrombopoietic-mesenchymal interaction that may facilitate both endochondral ossification and pletelet maturation via CCN2. J. Cell Commun. Signal., 4, 5-14, 2010. 55) Effect of spherical silica additions on marginal gaps and compressive strength of experimental glass ionomer cement mixtures; M. Irie, N. Nagaoka, Y. Tamada, Y. Maruo, G. Nishigawa, S. Minagi, K. Suzuki, W. J. Finger. American Journal of Dentistry, 24, 657-672, 2010 56) Nano-controlled molecular interaction at adhesive interfaces for hard tissue reconstruction; Yoshihara K, Yoshida Y, Nagaoka N, Fukegawa D, Hayakawa S, Mine A, Nakamura M, Minagi S, Osaka A, Suzuki K, Van Meerbeek B., Acta Biomaterialia, 6, 3573-3582, 2010 57) Effect of a new titanium coating material (CaTiO3-aC) prepared by thermal decomposition method on osteoblastic cell response; M. Inoue, A.P. Rodriguez, T. Takagi, N. Katase, M. Kubota, N. Nagai, H. Nagatsuka, M. Inoue, N. Nagaoka, S. Takagi, K. Suzuki., Journal of Biomaterials Applications, 24, 657-672, 2010 58) Mechanical properties of a resin-modified glass ionomer cement for luting: effect of adding spherical silica filler; E. Lihua, M. Irie, N. Nagaoka, T. Yamashiro and K. Suzuki, Journal of Dental Research, 29, 253-261, 2010 59) Kawata K, Kubota S, Eguchi T, Moritani NM, Shimo T, Kondo, S, Nishida T, Minagi S, Takigawa M. Role of the low-density lipoprotein-1 in regulation of chondrocyte differentiation. J. Cell. Physiol., 222(1):138-48, 2010 60) Hikichi Y, Yoshimura K, Takigawa M. All-trans retinoic acid-induced ADAM28 degrades proteoglycans in human chondrocytes. Biochem Biophys Res Commun. 386(2):294-299, 2009. 61) Sakai Y, Balam TA, Kuroda S, Tamamura N, Fukunaga T, Takigawa M, Takano-Yamamoto T.: CTGF and apoptosis in mouse osteocytes induced by tooth movement. J Dent Res., 88(4):345-50, 2009. 62) Aoyama E, Hattori T, Hoshijima M, Araki D, Nishida T, Kubota S, Takigawa M.: N-terminal domains of CCN protein 2/connective tissue growth factor bind to aggrecan. Biochem. J., 420: 413-420, 2009. 63) Ohgawara, T., Kubota, S., Kawaki, H., Kondo, S., Eguchi, T., Kurio, N., Aoyama, E., Sasaki, A. Takigawa, M. Regulation of chondrocytic phenotype by micro RNA 18a: Involvement of Ccn2/Ctgf as a major target gene. FEBS Lett. 583: 1006-1010, 2009. 64) Maeda, A., Nishida, T., Aoyama, E., Kubota, S., Lyons, K. M., Kuboki, T., Takigawa, M. CCN family 2/connective tissue growth factor modulates BMP signaling as a signal conductor, which action regulayes the proliferation and differentiation of chondrocytes. J. Biochem. 145(2): 207-216, 2009. 65) Nishida, T. Kondo, S., Maeda, A., Kubota, S., Lyons, K. M., Takigawa, M. CCN family 2/ connective tissue growth factor (CCN2/CTGF) regulates the expression of Vegf through Hif-1a expression in a chondrocytic cell line, HCS-2/8, under hypoxic condition. Bone 44 (1): 24-31, 2009.  66) Takeuchi, H., Kubota, S., Murakashi, E., Fukada, T., Hashimoto, S., Takigawa, M. and Numabe, Y. Effect of TGF-β1 on CCN2/CTGF in normal human gingival fibroblasts and periodontal ligament cells. J. periodontal. Res., 44: 161-169, 2009. 67) N. Namba, Y. Yoshida, N. Nagaoka, S. Takashima, K.Matsuura-Yoshimoto, H. Maeda, B. Van Meerbeek, K. Suzuki, S. Takashiba: Antibacterial effect of bactericide immobilized in resin matrix. Dent Mater, 25, 424-430, 2009 68) Hirano Y, Ishiguro N, Sokabe M, Takigawa M and Naruse K: Effects of tensile and compressive strains on response of a chondrocytic cell line embedded in type I collagen gel. J Biotechnol., 133, 245-252, 2008. 69) Heino TJ, Chagin AS, Takigawa M and Savendahl L: Effects of alendronate and pamidronate on cultured rat metatarsal bones: failure to prevent dexamethasone-induced growth retardation. Bone, 42,702-709, 2008. 70) Vincourt, JB., Vibnaud, J. M., Lionnection, F., Sirveaux, F., Kawaki, H., Marchal, S., Lomazzi, S., Plenat, F., Netter, P., Takigawa, M., Mainard, D., Magdalou, J. Increased expression of matrilin-3 not only in osteoarthritic articular cartilage but also in cartilage-forming tumors, and down-regulation of SOX9 via epidermal growth factor domain 1-dependent signaling. Arthritis Rheum. 58(9): 2798-2808, 2008. 71) Shimo, T. Kubota, S., Goda, T., Yoshihama, Y., Kurio, N., Nishida, T., Ng, P. S., Endo, K., Takigawa, M. Sasaki, A. Clinical significance and pathogenic function of connective tissue growth factor (CTGF/CCN2) in osteolytic mandibular squamous cell carcinoma. Anticancer Res. 28 (4C): 2343-2348, 2008. 72) Mukudai, Y., Kubota, S., Kawaki, H., Kondo, S. Eguchi, T., Sumiyoshi, K., Ohgawara, T., Shimo, T., Takigawa, M. Post-transcriptional regulation of chicken ccn2 gene expression by nucleophosmin/B23 during chondrocyte differentiation. Mol Cell Biol. 28, 6134-6147, 2008. 73) Kuroda, C., Kubota, S., Kawata, K., Aoyama, E., Sumiyoshi, K., Inoue, M., Minagi, S., Takigawa, M. Distribution, gene expression, and functional role of EphA4 during ossification. Biochem. Biophys. Res..Commun. 374(1): 22-27, 2008. 74) Motoki, T., Sugiura, Y., Matsumoto, Y., Tsuji, T., Kubota, S., Takigawa, M., Gohda, E. Induction of hepatocyte growth factor expression by maleic acid in human fibroblasts through MAPK activation. J. Cell Biochem. 104(4): 1465-1476, 2008. 75) Hattori, T., Coustry, F., Stephens, S., Eberspaecher, H., Takigawa, M., Yasuda, H., de Crombrugghe, B. Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5. Nucleic Acids Res. 36(9): 3011-3024, 2008. 76) Kikuchi T., Kubota S., Asaumi K., Kawaki H., Nishida T., Kawata K., Mitani S., Tabata Y, Ozaki T., Takigawa M. Promotion of bone regeneration by CCN2 incorporated into gelatin hydrogel. Tissue Engineering Part A, 14, 1089-1098, 2008. 77) Sun G., Haginoya K., Wu Y., Chiba Y., Nakanishi T., Onuma A., Sato Y., Takigawa M., Iinuma K., Tsuchiya S. Connective tissue growth factor is overexpressed in muscles of human muscular dystrophy. J Neurol Sci. 267(1-2), 48-56, 2008. 78) Nishida T., Maeda A., Kubota S., Takigawa M. Role of mechanical-stress inducible protein Hcs24/CTGF/CCN2 in cartilage growth and regeneration: -Mechanical stress induces expression of Hcs24/CTGF/CCN2 in human chondrocytic cell line, HCS-2/8, rabbit hyaline costal chondrocytes and meniscus cells- Biorheology, 45(3-4):289-99, 2008. 79) Kawaki H., Kubota S., Suzuki A., Lazar, N., Yamada, T., Matsumura, T., Ohgawara, T., Maeda, T., Perbal, B. Lyons, K. M., Takigawa M. Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage. J. Bone Miner. Res. 23(11): 1751-1764, 2008. 80) Kawaki H., Kubota S., Suzuki A., Yamada T., Matsumura T., Mandai, T., Yao, M., Maeda T., Lyons K.M., Takigawa M. Functional requirement of CCN2 for intramembranous bone formation in embryonic mice. Biochem. Biophys. Res. Commun., 366(2):450-456, 2008. 81) Fujisawa T., Hattori T., Ono M., Uehara J., Kubota S., Kuboki T., Takigawa M. CCN family 2 / Connective tissue growth factor (CCN2/CTGF) stimulates proliferation and differentiation of auricular chondrocytes. Osteoarthritis and Cartilage, 16(7), 787-795, 2008. 82) Koitabashi N., Arai M., Niwano K., Watanabe A., Endoh M., Suguta M., Yokoyama T., Tada H., Toyama T., Adachi H., Naito S., Oshima S., Nishida T., Kubota S., Takigawa M., Kurabayashi M. Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure. Eur. J. Heart Failure, 10 373-379, 2008. 83) Eguchi T, Kubota S, Kawata K, Mukudai Y, Uehara J, Ohgawara T, Ibaragi S, Sasaki A, Kuboki T, Takigawa M. Novel transcription factor-like function of human MMP3 regulating CTGF/CCN2 gene. Mol. Cell. Biol., 28: 2391-2413, 2008. 84) Doi H., Nishida K., Yorimitsu M., Komiyama T., Kadota Y., Tetsunaga T., Yoshida A., Kubota S., Takigawa M., Ozaki T. Interleukin-4 downregulates the cyclic tensile stress-induced matrix metalloproteinases-13 and cathepsin B expression by rat normal chondrocytes. Acta Medica Okayama, 62(2), 119-126, 2008. 85) Matsumoto Y., Motoki T., Kubota S., Takigawa M., Tsubouchi H., Gohda E. Inhibition of tumor-stromal interaction through HGF-Met signaling by valproic acid. Biochem. Biophys. Res. Commun., 366(1):110-116, 2008. 86) Ono M., Kubota S., Fujisawa T., Sonoyama W., Kawaki H., Akiyama K., Oshima M., Nishida T., Yoshida Y., Suzuki K., Takigawa M., Kuboki T. Promotion of hydroxyapatite-associated, stem cell-based bone regeneration by CCN2. Cell Transplantation, 17(1-2), 231-240, 2008. 87) Ultrasonic Cleaning Influences Silica Coated Zirconia Bond Strength; G. Nishigawa, Y. Maruo, M. Irie, M. Oka, K. Yoshihara, S. Minagi,N. Nagaoka, Y. Yoshida and K. Suzuki, Dent Mater J, 27, 842-848, 2008 88) Oka M., Kubota S., Kondo S., Eguchi T., Kuroda C., Kawata K., Minagi S., Takigawa M. Gene expression and distribution of connective tissue growth factor (CCN2/CTGF) during secondary ossification center formation. J. Histochem. Cytochem., 55: 1245-1255, 2007. 89) Miyamato Y., Mabushi A., Shi D., Kubo T., Takatori Y., Saito S., Fujioka M., Sudo A., Uchida A., Yamamoto S., Ozaki K., Takigawa M., Tanaka T., Nakamura Y., Jiang Q., Ikegawa S. A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis. Nat. Genet. 39, 529-533, 2007. 90) Nishida T., Kawaki H., Baxter R.M., DeYoung A., Takigawa M., Lyons K.M. CCN2 (Connective tissue growth factor) is essential for extracellular matrix production and integrin signaling in chondrocytes. J Cell Commun Signal, 1, 45-58, 2007. 91) Eguchi T., Kubota S., Kawata K., Mukudai Y., Ohgawara T., Miyazono K., Nakao K., Kondo S., Takigawa M. Different transcriptional strategies for ccn2/ctgf gene induction between human chondrocytic and breast cancer cell lines. Biochimie. 89(3): 278-288, 2007. 92) Koitabashi N., Arai M., Kogure S., Niwano K., Watanabe A., Aoki Y., Maeno T., Nishida T., Kubota S., Takigawa M., Kurabayashi M. Increased connective tissue growth factor relative to brain natriuretic Peptide as a determinant of myocardial fibrosis. Hypertension 49(5): 1120-1127, 2007. 93) Ono M., Kubota S., Fujisawa T., Sonoyama W., Kawaki H., Akiyama K., Ohima M., Nishida T., Yoshida Y., Suzuki K., Takigawa M., Kuboki T. Promotion of attachment of human bone marrow stromal cells by CCN2. Biochem Biophys Res Commun. 357(1): 20-25, 2007. 94) Yanagita T., Kubota S., Kawaki H., Kawata K., Kondo S., Takano-Yamamoto T., Tanaka S., Takigawa M. Expression and physiological role of CCN4/Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes. FEBS J. 274(7): 1655-1665, 2007. 95) Chagin A. S., Karimian E., Zaman F., Takigawa M., Chrysis D. and Savendahl L. Tamoxifen induces permanent growth arrest through selective induction of apoptosis in growth plate chondrocytes in cultured rat metatarsal bones. Bone, 40(5), 1415-1424, 2007. 96) Fushimi K., Nakashima S.,You F., Takigawa M., Shimizu K. Prostaglandin E(2) downregulates TNF-alpha-induced production of matrix metalloproteinase-1 in HCS-2/8 chondrocytes by inhibiting Raf-1/MEK/ERK cascade through EP4 prostanoid receptor activation. J. Cell Biochem. 100(3): 783-793, 2007. 97) Hirano Y., Ishiguro N., Sokabe M., Takigawa M. and Naruse K. Effects of tensile and compressive strains on response of a chondrocytic cell line embedded in type I collagen gel. J. Biotechnol. 133(2): 245-252, 2007. 98) Zaman F, Menendez-Benito V, Eriksson E, Chagin AS, Takigawa M, Fadeel B, Dantuma NP, Chrysis D and Savendahl L Proteasome inhibition up-regulates p53 and apoptosis-inducing factor in chondrocytes causing severe growth retardation in mice. Cancer Res. 67(20): 10078-10086, 2007. 99) Mori M., Nakajima M., Mikami Y., Seki S., Takigawa M., Kubo T., Ikegawa S. Transcriptional regulation of the cartilage intermediate layer protein (CILP) gene. Biochem. Biophys. Res. Commun. 341, 121-127, 2006. 100) Aiga A., Asaumi K., Lee Y. J., Kadota H., Mitani S., Ozaki T., Takigawa M. Expression of neurotrophins and their receptors tropomyosin-related kinases (Trk) under tension-stress during distraction osteogenesis.. Acta Med Okayama., 60(5):267-277, 2006. 101) Kondo, S., Kubota, S., Sugahara, T. and Takigawa, M. Expression and regulation of an anti-sense RNA transcript from human connective tissue growth factor gene in human cells. Asian J. Oral Mallilofa. Surg., 18: 172-179, 2006. 102) Shimo, T., Kubota, S., Yoshioka, N., Ibaragi, S., Isowa, S., Eguchi, T., Sasaki, A., Takigawa, M. Pathogenic role of connective tissue growth factor (CCN2/CTGF) in osteolytic metastasis of breast cancer. J. Bone Miner. Res., 21:1045-1059, 2006. 103) Kubota, S., Kawaki, H., Kondo, S., Yosimichi, G., Minato, M., Nishida, T., Hanagata, H., Miyauchi, A., Takigawa, M. Multiple activation of mitogen-activated protein kinases by purified independent CCN2 modules in vascular endothelial cells and chondrocytes in cultue. Biochimie, 88(12), 1973-1981, 2006. 104) Kawata, K., Eguchi, T., Kubota, S., Kawaki, H., Oka, M., Minagi, S., and Takigawa, M. : Possible role of LRP1, a CCN2 receptor, in chondrocytes. Biochem Biophys Res Commun., 345(2):552-559, 2006. 105) Chagin, A. S., Chrysis, D., Takigawa, M., Ritzen, E. M., and SavendahI, L. Locally produced estrogen promotes fetal rat metatarsal bone growth; an effect mediated through increased chondrocyte proliferation and decreased apoptosis. J. 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Bone, 38, 853-863, 2006. 109) Kondo, S., Tanaka, N., Kubota, S., Mukudai, Y., Yosimichi, G., Sugahara T., and Takigawa, M.: Novel angiogenic inhibitor DN-9693 that inhibits post-transcriptional induction of connective tissue growth factor (CTGF/CCN2) by vascular endothelial growth factor (VEGF) in human endothelial cells. Molecular Cancer Therapeutics 5, 129-137, 2006. 110) Kondo, S., Kubota, S., Mukudai, Y., Moritani, N., Nishida, T., Matsushita, H., Matsumoto, S., Sugahara, T. and Takigawa, M.: Hypoxic regulation of stability of connective tissue growth factor/CCN2 mRNA by 3'-untranslated region interacting with a cellular protein in human chondrosarcoma cells. Oncogene, 25(7): 1099-1110, 2006. 111) Maeda, T., Jikko, A., Abe, M., Yokohama-Tamaki, T., Akiyama, H., Furukawa, S., Takigawa, M. and Wakisaka, S.: Cartducin, a Paralog of acrp30/adiponectin, is induced during chondrogenic differentiation and promotes proliferation of chondrogenic precursors and chondrocytes. J. Cell. 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Cancer Genet Cytogenet. 158(2), 148-155, 2005. 118) Moritani, NH., Kubota, S., Sugahara, S. and Takigawa, M.: Comparable response of ccn1 with ccn2 genes upon arthritis: An in vitro evaluation with a human chondrocytic cell line stimulated by a set of cytokines. Cell Communication and Signaling, 3(1), 6, 2005. 119) Yamaai, T., Nakanishi, T., Asano, M., Nawachi, K., Yosimichi, G., Ohyama, K., Komori, T., Sugimoto, T. and Takigawa, M.: Gene expression of connective tissue growth factor (CTGF/CCN2) in calcifying tissues of normal and cbfa1-null mutant in late stage of mouse embryonic development. J. Bone Miner. Metab., 23, 280-288, 2005. 120) Nakao, K., Kubota, S., Doi, H., Eguchi, T., Oka, M., Fujisawa, T., Nishida, T. and Takigawa, M.: Collaborative action of M-CSF and CTGF/CCN2 in articular chondrocytes:possible regenerative roles in articular cartilage metabolism. 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Biochem Biophys Res Commun., 322, 22-28, 2004 141) Jung, y., Jong, J., Ryoo, H., Kim, H., Kim, Y., Park, E., Si, H., Kim, S., Takigawa, M., Lee, B., Park, R, Kim, I., Choi, J.: Gene expression profile of human chondrocyte HCS 2/8 cell line by EST sequencing analysis. Gene, 330, 85-92, 2004. 142) Kadota, H., Nakanishi, T., Asaumi, K., Yamaai, T., Nakata, E., Mitani, S., Aoki, K., Aiga, A., Inoue, H and Takigawa, M.: Expression of Connective Tissue Growth Factor/Hypertrophic Chondrocyte-Specific Gene Product 24 (CTGF/Hcs24/CCN2) During Distraction Osteogenesis. J. Bone Miner. Metab., 22(4), 293-302, 2004. 143) Nishida, T., Kubota, S., Kojima, S., Kuboki, T., Nakao, K., Kushibiki, T., Tabata, Y. and Takigawa. M. Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor). J. Bone Miner. 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Ikegame, J Electron Microscopy, 54, 29-34, 2004 147) Induction of activated caspase-3-immunoreactivity and apoptosis in the trigeminal ganglion neurons by neonatal peripheral nerve injury; T. Sugimoto, H. Jin, M. Fujita, T. Fukunaga, N. Nagaoka, Y. Yamaai and H. Ichikawa, Brain Research, 1017 (1), 238-243, 2004 148) T. Sugimoto, H. Jin, M. Fujita, T. Fukunaga, N. Nagaoka, T. Yamaai and H. Ichikawa.: Induction of activated caspase-3-immunoreactivity and apoptosis in the trigeminal ganglion neurons by neonatal peripheral nerve injury. Brain Res., 1017: 238-243, 2004 149) H. Ichikawa, S. Matsuo, I. Silos-Santiago, M.F. Jacquin and T. Sugimoto.: The development of myelinated nociceptors is dependent upon trks in the trigeminal ganglion. Acta Histochem., 106: 337-343, 2004 150) H. Ichikawa and T. Sugimoto.: Neurocalcin-immunoreactive neurons in the petrosal ganglion innervate the taste bud. Brain Res., 1017: 244-247, 2004 151) H. Ichikawa, S.C. Lin, S.Y. Tsai, M.J. Tsai and T. Sugimoto: Effect of mCOUP-TF1 deficiency on the glossopharyngeal and vagal sensory ganglia. Brain Res., 1014: 247-250, 2004 152) H. Ichikawa, Z. Mo, M. Xiang and T. Sugimoto: Effect of Brn-3a deficiency on parvalbumin-immunoreactive primary sensory neurons in the dorsal root ganglion. Dev. Brain Res., 150: 41-45, 2004 153) H. Ichikawa, T. Fukunaga, H.W. Jin, M. Fujita, T. Takano-Yamamoto and T. Sugimoto T: VR1-, VRL-1- and P2X3 receptor-immunoreactive innervation of the rat temporomandibular joint. Brain Res., 1008: 131-136, 2004 154) H. Ichikawa, S. Gouty, J. Regalia, C.J. Helke and T. Sugimoto: Ca2+/calmodulin-dependent protein kinase II in the rat cranial sensory ganglia. Brain Res., 1005: 36-43, 2004 155) H. Ichikawa and T. Sugimoto.: The co-expression of P2X3 receptor with VR1 and VRL-1 in the rat trigeminal ganglion. Brain Res., 998: 130-135, 2004 156) Fukunaga, T., Yamashiro, T., Oya, S., Takeshita, N., Takigawa, M. and Takano-Yamamoto, T.: Connective tissue growth factor mRNA expression pattern in cartilages is associated with their type I collagen expression. Bone, 33(6), 911-8, 2003. 157) Kawaki H, Kubota S, Minato M, Moritani, NH, Hattori, T, Hanagata H, Kubota M, Miyauchi A., Nakanishi T, and Takigawa M.: Novel enzyme-linked ommunosorbent assay systems for the quantitative analysis of connective tissue growth factor (CTGF/Hcs24/CCN2): Detection of HTLV-I Tax-induced CTGF from a human carcinoma cell line. DNA Cell Biol., 22, 641-648, 2003. 158) Fujisawa T, Kuboki T, Kasai T, Sonoyama W, Kojima S, Uehara J, Komori C, Yatani H, Hattori T, Takigawa M.: A repetitive steady mouth opening induced osteoarthritis-like lesion in rabbit temporomandibular joint. J. Dent. Res., 82, 731-735, 2003. 159) Kubota S, Moritani N H, Kawaki H, Mimura H, Minato M and Takigawa M.: Transcriptional induction of connective tissue growth factor/ hypertrophic chondrocyte specific 24 (CTGF/Hcs24) gene by dexamethasone in human chondrocytic cells. Bone, 33, 694-702, 2003. 160) Kanyama M, Kuboki T, Akiyama K, Nawachi K, Miyauchi F M, Yatani H, Kubota S, Nakanishi T and Takigawa M.: Connective tissue growth factor expressed in rat alveolar bone regeneration sites after tooth extraction. Archs. Oral Biol., 48, 723-730, 2003. 161) Hattori T, Kawaki H, Kubota S, Yutani Y, de Crombrugghe B, von der Mark K and Takigawa M.: Downregulation of a rheumatoid arthritis-related antigen (RA-A47) by an antisense oligonucleotide induces inflammatory factors and changes its localization of cell surface with tetraspanin protein CD9 in a human chondrosarcoma-derived cell line HCS-2/8. J. Cell. 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(IF=5.463) 165) Moritani NH, Kubota S, Kondo S, Nishida T, Kawaki H, Sugahara T, Takigawa M: Suppressive effect of overexpressed connective tissue growth factor on tumor cell growth in a human oral squamous cell carcinoma-derived cell line. Cancer Lett., 192, 205-214, 2003. 166) Mukudai Y., Kubota, S., and Takigawa, M.: Conserved repressive regulation of connective tissue growth factor/ hypertrophic chondrocyte-specific gene 24 (ctgf/hcs24) enabled by different elements and factors among vertebrate species. Biol. Chem., 384, 1-9, 2003. 167) Inoue T, Okada H, Kobayashi T, Watanabe Y, Kanno Y, Kopp JB, Nishida T, Takigawa M, Ueno M, Nakamura T, Suzuki H.: Hepatocyte growth factor counteracts transforming growth factor-beta1, through attenuation of connective tissue growth factor induction, and prevents renal fibrogenesis in 5/6 nephrectomized mice. FASEB J 17, 268-270, 2003. 168) Karjalainen HM, Sironen RK, Elo MA, Kaarniranta K, Takigawa M, Helminen HJ, Lammi MJ.: Gene expression profiles in chondrosarcoma cells subjected to cyclic stretching and hydrostatic pressure. A cDNA array study. Biorheology 2003;40(1,2,3):93-100 169) H. Ichikawa and T. Sugimoto.: Calcium-binding protein-immunoreactive innervation of the rat vibrissa. Brain Res., 970: 226-231, 2003. 170) H. Ichikawa and T. Sugimoto.: Kv1.2-immunoreactive primary sensory neurons in the rat trigeminal ganglion. Brain Res., 974: 222-227, 2003. 171) H. Ichikawa and T. Sugimoto.: The co-expression of VR1 and VRL-1 in the rat vagal sensory ganglia. Brain Res., 980: 293-296, 2003. 172) H. Ichikawa and T. Sugimoto.Pituitary adenylate cyclase-activating polypeptide-immunoreactive nerve fibers in rat and human tooth pulps. Brain Res., 980: 288-292, 2003. 173) H. Ichikawa, S. Schulz, V. Hollt and T. Sugimoto: The somatostatin sst2A receptor in the rat trigeminal ganglion. Neuroscience, 120: 807-813, 2003. Shimizu H, Nishitani Y, Yamada T, Nishida T, Takigawa M, Yoshiyama M: Development of dentin regerenation therepy: Expression of type I collagen and alkaline phosphatase induced by CTGF in human cultured dental pulp. J. Hard Tissue Biol., 11, 62-67, 2002. 174) Yosimichi, G., Kubota, S., Hattori, T., Nishida, T., Nawachi K, Nakanishi, T., Kamada, M, Takano-Yamamoto. and Takigawa, M. : CTGF/Hcs24 interacts with the cytoskeletoal protein actin in chondrocytes. Biochem. Bophys. Res. Commun., 299, 755-761, 2002. 175) Kobayashi, H., Suzuki, M., Kanayama, N., Nishida, T., Takigawa, M. and Terao, T.:CD44 stimulation by fragmented hyaluronic acid induces upregulation of urokinase-type plasminogen activator and its receptor and subsequently facilitates invasion of human chondrosarcoma cells. Int. J. Cancer, 102(4), 379-89, 2002. 176) Inoue T, Okada H, Kobayashi T, Watanabe Y, Kikuta T, Kanno Y, Takigawa M, Suzuki H. 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Biorheology, 39(1,2), 111-117, 2002. 190) Suzuki, M., Kobayashi, H., Fujie, M., Nishida, T., Takigawa, M., Kanayama, N. and Terao, T.:Kunitz-type protease inhibitor bikunin disrupts phorbol ester-induced oligomerization of CD44 variant isoforms containing epitope v9 and subsequently suppresses expression of urokinase-type plasminogen activator in human chondrosarcoma cells. J. Biol. Chem., 277(10), 8022-8032, 2002. 191) H. Ichikawa and T. Sugimoto.: Co-expression of VRL-1 and calbindin D-28k in the rat sensory ganglion. Brain Res., 924: 109-112, 2002. 192) H. Ichikawa, T. Yamaai, Z. Mo, M. Xiang and T. Sugimoto.: Effect of Brn-3a deficiency on CGRP-immunoreactivity in the dorsal root ganglion. Neuroreport, 13: 409-412, 2002. 193) H. Ichikawa, T. Sugimoto.: The co-expression of ASIC3 with calcitonin gene-related peptide and parvalbumin in the rat trigeminal ganglion. Brain Res., 943: 287-291, 2002. 194) H. Ichikawa,T. Yamaai, D. M. Jacobowitz, Z. Mo, M. Xiang and T. Sugimoto.Effect of Brn-3a deficiency on parvalbumin-, calbindin D-28k-, calretinin-and calcitonin gene-related peptide-immunoreactive primary sensory neurons in the trigeminal ganglion. Neuroscience, 113: 537-546, 2002. 195) H. Ichikawa, Z. Mo, M. Xiang and T. Sugimoto. Effect of Brn-3a deficiency on nociceptors and low-threshold mechanoreceptors in the trigeminal ganglion. Molec. Brain Res., 104: 240-245, 2002. 196) H. Ichikawa and T. Sugimoto.: The difference of osteocalcin-immunoreactive neurons in the rat dorsal root and trigeminal ganglia: co-expression with nociceptive transducers and central projection. Brain Res., 958: 459-462, 2002. 197) Pan, L-H., Yamauchi, M., Uzuki, M., Nakanishi, T., Takigawa, M., Inoue, H. and Sawai, T.:Type Ⅱ albeolar epithelial cells and interstitial fibroblasts express connective tissue growth factor in IPF. Eur. Respir. J. 17, 1220-1227, 2001 198) Yamashiro, T., Fukunaga, T., Kobashi, N., Kamioka, H., Nakanishi , T., Takigawa, M. and Takano-Yamamoto, T.: Mechanical stimulation induces CTGF expression in rat osteocytes. J. Dent. Res., 80(2), 461-465, 2001. 199) Kubota, S., Mukudai, Y., Hattori, T., Eguchi, T., Kondo, S. and Takigawa, M.:Cell-type-specific trans-activation of herpes simplex virus thymidine kinase promoter by the human T-cell leukemia virus TypeⅠ Tax protein. DNA cell Biol., 20(9), 563-568, 2001. 200) Yosimichi, G., Nakanishi, T., Nishida, T., Hattori, T., Takano-Yamamoto, T. and Takigawa, M. : CTGF/Hcs24 induces chondrocyte differentiation through p44/42 MAPK/exracellular-signal regulated kinase (ERK). Eur. J. Biochem. 268, 1-9, 2001. 201) Shimo, T., Kubota, S., Kondo, S., Nakanishi, T., Sasaki, A., Mese, H., Matsumura, T. and Takigawa, M.: Connectivetissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line. Cancer Lett., 174, 57-64, 2001. 202) Shimo, T., Nakanishi, T., Nishida, T., Asano, M., Sasaki, A., Kanyama, M., Kuboki, T., Matsumura, T. and Takigawa, M. : Involvement of CTGF, a hypertrophic chondrocyte-specific gene product, in tumor angiogenesis. Oncology, 61, 315-322, 2001. 203) Sakai, T., Kambe, F., Mitsuyama, H., Ishiguro, N., Kurokouchi, K., Takigawa, M., Iwata, H. and Seo, H.: Tumor necrosis factor α induces expression of genes for matrix degradation in human chondrocyte-like HCS-2/8 cells through activation of NF-KB: Abrogation of the tumor necrosis factor α effect by proteasome inhibitors. J. Bone Miner. Res., 16, 1272-1280, 2001. 204) Kubota, S., Eguchi, T., Shimo, T., Nishida, T., Hattori, T., Kondo, S., Nakanishi, T. and Takigawa, M.: Novel mode of processing and secretion of connective tissue growth factor/ecogenin (CTGF/Hcs24) in chondrocytic HCS-2/8 cells. Bone, 29(2), 155-161, 2001. 205) Tsuboi, Y., Nakanishi, T., Takano-Yamamoto, T., Miyamoto, M., Yamashiro, T. and Takigawa, M.: Mitogenetic effect of neurotrophins on periodonatal ligament cell line. J. Dent. Res., 80(3), 881-886, 2001. 206) Eguchi, T., Kubota, S., Kondo, S., Shimo, T., Hattori, T., Nakanishi, T., Kuboki, T., Yatani, H. and Takigawa, M.: Regulatory mechanism of human connective tissue growth factor (ctgf/hcs24) gene expression in a human chondrocytic cell line, Hcs-2/8. J. Biochem., 130(1), 79-87, 2001. 207) Hirashima, Y., Kobayashi, H., Suzuki, M., Tanaka, Y., Kanayama, N., Fujie, M., Nishida, T., Takigawa, M. and Terao, T.: Characterization of binding properties of uninary trypsin inhibitor (UTI) to cell-associated binding sites on human chondrosarcoma cell line HCS-2/8. J. Biol. Chem., 276(17), 13650-6, 2001. 208) Boumediene, K., Takigawa, M. and Pujol, J-P.: Cell density-dependent proliferative effects of transforming growth factor (TGF)-β1, β2, and β3 in human chondrosarcoma cells HCS-2/8 are associated with changes in the expression of TGF-β receptor type Ⅰ. Cancer Invest., 19, 485-495, 2001. 209) Nakanishi, T., Yamaai, Y., Asano, M., Nawachi, K., Suzuki, M., Sugimoto, T. and Takigawa, M.: Overexpressions of connective tissue growth factor/hypertrophic chondrocyte specific gene product 24(CTGF/Hcs24) decreases bone density in adult mice and induces dwarfism. Biochem. Biophys. Res. Commun., 281, 678-681, 2001. 210) Sekine, T., Masuko-Hongo, K., Matui, T., Asahara, H., Takigawa, M., Nishioka, K. and Kato, T.: YKL-39, a human cartilage-related protein, is recognized as a target antigen in patients with rheumatoid arthritis. Ann. Rheum. Dis., 60(1), 49-54, 2001. 211) Ohashi, S., Kubo, T., Ikeda, T., Arai, Y., Takahashi, K., Hirasawa, Y., Takigawa, M., Satoh, E., Imanishi, J. and Mazda, O. : Cationic polymer-mediated genetic transduction into cultured human chondrosarcoma-derived HCS-2/8 cells. J. Orthop. Sci., 6(1), 75-81, 2001. 212) Kubo, T., Arai , Y., Takahashi, K., Ikeda, T., Ohashi, S., Kitajima, I., Mazda, O. and Takigawa, M., Imanishi, J. and Hirasawa, Y.: Expression of transduced HSP70 gene protects chondrocytes from stress. J. Rheumatol., 28(2), 330-335, 2001. 213) Hattori, T., Kubota, S., Yutani, Y., Fujisawa, T., Nakanishi, T., Takahashi, K. and Takigawa, M.: Change in cellular localization of a rheumatoid arthritis-related antigen (RA-A47) with downregulation upon stimulation by inflammatory cytokines in chondrocytes. J. Cell. Physiol., 186, 268-281, 2001. 214) T. Sugimoto, A. Takeyama, M. Fujita, H. Ichikawa and T. Takano-Yamamoto: Peripheral neuroglial death induced by cisplatin administration in newborn rats. Neuroreport, 12: 137-140, 2001. 215) H. Ichikawa and T. Sugimoto.: VR1-immunoreactive primary sensory neurons in the rat trigeminal ganglion. Brain Res., 890: 184-188, 2001. 216) H. Ichikawa, S. Matsuo, I. Silos-Santiago, M. F. Jacquin and T. Sugimoto.95 Developmental dependency of merkel endings on trks in the palate. Molec. Brain Res., 88: 171-175, 2001. 217) H. Ichikawa and T. Sugimoto.: VRL-1 immunoreactivity in the rat cranial autonomic ganglia. Neuroreport, 12: 1597-1599, 2001. 218) H. Ichikawa, K. Yamashita, T. Takano-Yamamoto and T. Sugimoto.98 Osteopontin-immunoreactivity in the rat trigeminal ganglion and trigeminal sensory nuclei. 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Endocrinology, 141(1), 264-273, 2000. Citation 155 229) Nishida, T., Nakanishi, T., Asano, M., Shimo, T. and Takigawa, M.: Effects of CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, on the proliferation and differentiation of osteoblastic cells in vitro. J. Cell. Physiol., 184, 197-206, 2000. Citation 116 230) Sato, S., Nagaoka, T., Hasegawa, M., Tamatani, T., Nakanishi, T., Takigawa, M. and Takehara, K.: Serum levels of connective tissue growth factor are elevated in patients with systemic sclerosis: Association with the extent of skin sclerosis and the severity of pulmonary fibrosis. J. Rheumatol., 27(1), 149-154, 2000. Citation 131 231) H. Ichikawa, S. Matsuo, I. Silos-Santiago and T. Sugimoto 232) :Developmental dependency of Meissner corpuscles on trkB but not trkA or trkC. Neuroreport 11: 259-262, 2000. 233) Y.-F. He, H. Ichikawa and T. Sugimoto: The effect of neonatal capsaicin on the c-Fos-like immunoreactivity induced in subnucleus oralis neurons by noxious intraoral stimulation. Brain Res., 860: 203-207, 2000. 234) H. Ichikawa, T. Itota, Y. Nishitani, Y. Torii, K. Inoue and T. Sugimoto: Osteopontin-immunoreactive primary sensory neurons in the rat spinal and trigeminal nervous systems. Brain Res., 863: 276-281, 2000. 235) H. Ichikawa, H. Hidaka and T. Sugimoto: Neurocalcin-immunoreactive primary sensory neurons in the trigeminal ganglion provide myelinated innervation to the tooth pulp and periodontal ligament. Brain Res., 864: 152-156, 2000. 236) T. Sugimoto, Y. L.. Li, H. Kishimoto, M. Fujita and H. Ichikawa Compensatory projection of primary nociceptors and c-fos induction in the spinal dorsal horn following neonatal sciatic nerve lesion. Exp. Neurol., 164: 407-414, 2000. 237) H. Ichikawa and T. 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Pain, 14, 20-30, 1999. 241) Mori, T., Kawara, S., Shinozaki, M., Hayashi, N., Kakinuma, T., Igarashi, A., Takigawa, M., Nakanishi, T. and Takehara, K.: Role and interaction of connective tissue growth factor with transforming growth factor-β in persistent fibrosis: A mouse fibrosis model. J. Cell. Physiol., 181(1), 153-159, 1999. Citation 244 242) Shimo, T., Nakanishi, T., Nishida, T., Asano, M., Kanyama, M., Kuboki, T., Tamatani, T., Tezuka, K., Takemura, M., Matsumura, T. and Takigawa, M.: Connective tissue growth factor induces the proliferation, migration and tube formation of vascular endothelial cells in vitro and angiogenesis in vivo. J. Biochem., 126(1), 137-145, 1999. Citation 267 243) Kondo, Y., Nakanishi, T., Takigawa, M. and Ogawa, N.: Immunohistochemical localization of connective tissue growth factor in the rat central nervous system. Brain Res., 834(1-2), 146-151, 1999. 244) Kubota, S., Hattori, T. 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Oral Biol., 44(9), 701-709, 1999. 248) Kuboki, T., Hattori, T., Mizushima, T., Kanyama, M., Fujisawa, T., Yamashita, A. and Takigawa, M.: Detection of specific antibodies against human cultured chondrosarcoma (HCS-2/8) and osteosarcoma (Saos-2) cells in the serum of patients with osteoarthritis of the temporomandibular joint. Arch. Oral Biol., 44(5), 403-414, 1999. 249) Yutani, Y., Yano, Y., Ohashi, H., Takigawa, M. and Yamano, Y.: Cartilaginous differentiation in the joint capsule. J. Bone Miner. Metab., 17(1), 7-10, 1999. 250) T. Sugimoto, A. Takeyama, C. Xiao, T. Takano-Yamamoto and H. Ichikawa : Electron microscopic demonstration of nick end-labeled DNA fragments during capsaicin-induced apoptosis of trigeminal primary neurons in neonatal rats. Brain Res., 818: 147-152, 1999. 251) T. Sugimoto, C. Xiao, A. Takeyama, Y. F. He, T. Takano-Yamamoto, and H. Ichikawa: Apoptotic cascade of neurons in the subcortical sensory relay nuclei following the neonatal infraorbital nerve transection. Brain Res., 824: 284-290, 1999. 252) H. Ichikawa, T. Itota, Y. Torii, K. Inoue and T. Sugimoto : Osteocalcin-immunoreactive primary sensory neurons in the rat spinal and trigeminal nervous systems. Brain Res., 838: 205-209, 1999. 253) H. Ichikawa and T. Sugimoto: Peptide 19-immunoreactive primary sensory neurons in the rat trigeminal ganglion. Brain Res., 846: 274-279, 1999.

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