研 究 成 果

       

 当施設を利用した講座別 研究成果(平成20年3月末現在)

  基礎系講座          臨床系講座         他学部


研究成果

当施設を利用した講座別研究成果(平成20年3月末現在)

(口腔機能解剖学)

Yamaai, T., Nakanishi, T., Asano, M., Nawachi, K., Yosimichi, G., Ohyama, K., Komoari, T., Sugimoto, T. and Takigawa, M.: Gene expression of connective tissue growth factor (CTGF/CCN2) in calcifying tissues of normal and cbfa1-null mutant in late stage of mouse embryonic development. J. Bone Miner. Metab., 23, 280-288, 2005.

Asano, M., Kubota, S., Nakanishi, T., Nishida, T., Yamaai, T., Yosimichi, G., Ohyama, K., Sugimoto, T., Murayama, Y. and Takigawa, M.: Effect of connective tissue growth factor (CCN2/CTGF) on proliferation and differentiation of mouse periodontal ligament-derived cells. Cell Commun Signal. 2005 Oct 5;3(1):11(Epub Journal)

 

 

(口腔生理学)

Kohjitani, A., Funahashi, M., Miyawaki, T., Hanazaki, M., Matsuo, R., and Shimada, M.: Peripheral N-methyl-D-aspartate receptors modulate nonadrenergic noncholinergic lower esophageal sphincter relaxation in rabbits. Anesthesia & Analgesia ?101, 1681-1688, 2006.

 

 

(口腔生化・分子歯科学)

Hattori, T., von der Mark, K., Kawaki, H., Yutani, Y., Kubota, S., Nakanishi, T., Eberspeacher, H., de Crombrugghe, B. and Takigawa, M. Downregulation of rheumatoid arthritis-related antigen RA-A47 (=HSP47/Colligin-2) in chondrocytic cell lines induces apoptosis and cell-surface expression of RA-A47 in association with CD9. J. Cell. Physiol.,202,191-204,2005.

Mukudai, Y., Kubota, S., Eguchi, T., Kondo, S., Nakao, K. and Takigawa, M.: Regulation of chicken ccn2 gene by interaction between RNA cis-element and trans-factor during differentiation of chondrocytes. J. Biol. Chem., 280, 3166-3177, 2005.

Nakao, K., Kubota, S., Doi, H., Eguchi, T., Oka, M., Fujisawa, T., Nishida, T. and Takigawa, M.: Collaborative action of M-CSF and CTGF/CCN2 in articular chondrocytes:possible regenerative roles in articular cartilage metabolism. Bone,36,884-892,2005.

Yamaai, T., Nakanishi, T., Asano, M., Nawachi, K., Yosimichi, G., Ohyama, K., Komoari, T., Sugimoto, T. and Takigawa, M.: Gene expression of connective tissue growth factor (CTGF/CCN2) in calcifying tissues of normal and cbfa1-null mutant in late stage of mouse embryonic development. J. Bone Miner. Metab., 23, 280-288, 2005.

Moritani, NH., Kubota, S., Sugahara, S. and Takigawa, M.: Comparable response of ccn1 with ccn2 genes upon arthritis: An in vitro evaluation with a human chondrocytic cell line stimulated by a set of cytokines. Cell Communication and Signaling, 3(1), 6, 2005.

Kubota, S., Mukudai, Y., Moritani, N.H., Nakao, K, Kawata, K. and K Takigawa, M.: Transcriptional repression by the cis-acting element of structure-anchored repression (CAESAR) of human ctgf/ccn2 mRNA. FEBS Lett, 579, 3751-3758, 2005.

Asano, M., Kubota, S., Nakanishi, T., Nishida, T., Yamaai, T., Yosimichi, G., Ohyama, K., Sugimoto, T., Murayama, Y. and Takigawa, M.: Effect of connective tissue growth factor (CCN2/CTGF) on proliferation and differentiation of mouse periodontal ligament-derived cells. Cell Commun Signal. 2005 Oct 5;3(1):11(Epub Journal)

Kondo, S., Kubota, S., Mukudai, Y., Moritani, N., Nishida, T., Matsushita, H., Matsumoto, S., Sugahara, T. and Takigawa, M.: Hypoxic regulation of stability of connective tissue growth factor/CCN2 mRNA by 3’-untranslated region interacting with a cellular protein in human chondrosarcoma cells. Oncogene, 16; 25(7): 1099-1110, 2005.

滝川正春:CCNファミリー:その構造と機能。細胞、37, 462-465, 2005.

Kondo, S., Tanaka, N., Kubota, S., Mukudai, Y., Yosimichi, G., Sugahara T., and Takigawa, M.: Novel angiogenic inhibitor DN-9693 that inhibits post-transcriptional induction of connective tissue growth factor (CTGF/CCN2) by vascular endothelial growth factor (VEGF) in human endothelial cells. Molecular Cancer Therapeutics 5, 129-137, 2006.

Yosimichi, G., Kubota, S., Nishida, T., Kondo, S., Yanagita, T., Nakao, K., Takano-Yamamoto, T. and Takigawa, M.: Roles of PKC, PI3K and JNK in multiple transduction of CCN2/CTGF signals in chondrocytes. Bone,38,853-863,2006.

Hoshijima M., Hattori, MT., Inoue,M., Araki, D, Hanagata, H. Miyauchi, A., and Takigawa, M. CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes integrin a5b1. FEBS Lett. 580(5),1376-1382,2006.

Kubota, S., and Takigawa, M. CCN family genes in the development and differentiation of cartilage tissues. Clin. Calcium,16(3),486-492,2006, Japanese.

Kawata, K., Eguchi, T., Kubota, S., Kawaki, H., Oka, M., Minagi, S., and Takigawa, M. Possible role of LRP1, a CCN2 receptor, in chondrocytes.? Biochem Biophys Res Commun., 345(2):552-559, 2006.

Hattori, T., Eberspaecher, H., Lu, J., Zhang, R., Nishida, T., Kahyo, T., Yasuda, H., de Crombrugghe, B.:Interactions between PIAS proteins and SOX9 results in an increase in the cellular concentrations of SOX9. J. Biol. Chem., 281(20):14417-14428, 2006.

Kubota, S., Kawaki, H., Kondo, S., Yosimichi, G., Minato, M., Nishida, T., Hanagata, H., Miyauchi, A., Takigawa, M. Multiple activation of mitogen-activated protein kinases by purified independent CCN2 modules in vascular endothelial cells and chondrocytes in cultue. Biochimie, 88(12), 1973-1981, 2006.

Shimo, T., Kubota, S., Eguchi, T., Ibaragi, S., Isowa, S., Yoshioka, N., Sasaki, A., Takigawa, M. Pathogenic role of connective tissue growth factor (CCN2/CTGF) in osteolytic metastasis of breast cancer. J. Bone Miner. Res.,21:1045-1059,2006.

Kubota, S. and Takigawa, M. CCN family proteins and angiogenesis: from embryo to adulthood. Angiogenesis. 10(1):1-11, 2007. ?

Kubota, S. and Takigawa, M. Role of CCN2/CTGF/Hcs24 in bone growth. Int Rev Cytol. 257:1-41, 2007.

Aiga A, Asaumi K, Lee YJ, Kadota H, Mitani S, Ozaki T, Takigawa M. Expression of neurotrophins and their receptors tropomyosin-related kinases (Trk) under tension-stress during distraction osteogenesis..Acta Med Okayama.,60(5):267-277, 2006.

Hattori T, Takigawa M. Autoantigen and molecular chaperone in rheumatoid arthritis--their roles in metabolism of chondrocytes] Clin Calcium. 16(9): 133-136, 2006, Japanese.

Yanagita T, Kubota S, Kawaki H, Kawata K, Kondo S, Takano-Yamamoto T, Tanaka S, Takigawa M. Expression and physiological role of CCN4/Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes. FEBS J.274(7):1655-1665,2007.

Yanagita T., Kubota S., Kawaki H., Kawata K., Kondo S., Takano-Yamamoto T., Tanaka S., Takigawa M.? Expression and physiological role of CCN4/Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes. FEBS J. 274(7): 1655-1665, 2007.

Ono M., Kubota S., Fujisawa T., Sonoyama W., Kawaki H., Akiyama K., Ohima M., Nishida T., Yoshida Y., Suzuki K., Takigawa M., Kuboki T. Promotion of attachment of human bone marrow stromal cells by CCN2. Biochem Biophys Res Commun. 25;357(1):20-5, 2007.

Eguchi T., Kubota S., Kawata K., Mukudai Y., Ohgawara T., Miyazono K., Nakao K., Kondo S., Takigawa M. Different transcriptional strategies for ccn2/ctgf gene induction between human chondrocytic and breast cancer cell lines. Biochimie. 89(3): 278-288, 2007.

Nishida T., Kawaki H., Baxter R.M., DeYoung A., Takigawa M., Lyons K.M. CCN2 (Connective tissue growth factor) is essential for extracellular matrix production and integrin signaling in chondrocytes. J Cell Commun Signal, 1, 45-58, 2007.

Oka M., Kubota S., Kondo S., Eguchi T., Kuroda C., Kawata K., Minagi S., Takigawa M. Gene expression and distribution of connective tissue growth factor (CCN2/CTGF) during secondary ossification center formation. J Histochem Cytochem, 55: 1245-1255, 2007.

Kubota, S., Yeger, H., Perbal B. and Takigawa. M. Report on the fourth international workshop on the CCN family of genes.? J. Cell Commun. Signal. 1: 59-65, 2007.

Ono M., Kubota S., Fujisawa T., Sonoyama W., Kawaki H., Akiyama K., Oshima M., Nishida T., Yoshida Y., Suzuki K., Takigawa M., Kuboki T. Promotion of hydroxyapatite-associated, stem cell-based bone regeneration by CCN2. Cell Transplantation, in press. 2008.

Doi H., Nishida K., Yorimitsu M., Komiyama T., Kadota Y., Tetsunaga T., Yoshida A., Kubota S., Takigawa M., Ozaki T. Interleukin-4 downregulates the cyclic tensile stress-induced matrix metalloproteinases-13 and cathepsin B expression by rat normal chondrocytes.? Acta Medica Okayama, in press, 2008.

Eguchi T, Kubota S, Kawata K, Mukudai Y, Uehara J, Ohgawara T, Ibaragi S, Sasaki A, Kuboki T, Takigawa M. Novel transcription factor-like function of human MMP3 regulating CTGF/CCN2 gene.? Mol. Cell. Biol., 28: 2391-2413, 2008.
Fujisawa T., Hattori T., Ono M., Uehara J., Kubota S., Kuboki T., Takigawa M. CCN family 2 / Connective tissue growth factor (CCN2/CTGF) stimulates proliferation and differentiation of auricular chondrocytes. Osteoarthritis and Cartilage, in press, 2008.

Kawaki H., Kubota S., Suzuki A., Yamada T., Matsumura T., Mandai, T., Yao, M., Maeda T., Lyons K.M., Takigawa M. Functional requirement of CCN2 for intramembranous bone formation in embryonic mice.? Biochem. Biophys. Res. Commun., 366(2):450-456, 2008.

Nishida T., Maeda A., Kubota S., Takigawa M. Role of mechanical-stress inducible protein Hcs24/CTGF/CCN2 in cartilage growth and regeneration: -Mechanical stress induces expression of Hcs24/CTGF/CCN2 in human chondrocytic cell line, HCS-2/8, rabbit hyaline costal chondrocytes and meniscus cells- Biorheology, in press, 2008.

Kikuchi T., Kubota S., Asaumi K., Kawaki H., Nishida T., Kawata K., Mitani S., Tabata Y, Ozaki T., Takigawa M. Promotion of bone regeneration by CCN2 incorporated into gelatin hydrogel. Tissue Engineering, in press, 2008.

 

 

 

(歯科薬理学)

Kitayama S., Sogawa C.: Regulated Expression and Function of the Somatodendritic Catecholamine Neurotransmitter Transporters., Journal of Pharmacological Sciences, 99, 121-127, 2005.

Carboxy terminal region regulates the functional expression of human norepinephrine transporter splice variants. Chiharu Sogawa, Kei Kumagai, Norio Sogawa, Katsuya Morita, Toshihiro Dohi, Shigeo Kitayama, Biochememical Journal 401, 185-195, 2007.

5-Methoxy-N, N-diisopropyltryptamine (Foxy), a selective and high affinity inhibitor of serotonin transporter. C. Sogawa, N. Sogawa, J. Tagawa, A. Fujimoto, K. Ohyama, M. Asanuma, M. Funada, S. Kitayama, Toxicology. Letters. in press.

                     

         

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