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700-8525  岡山市鹿田町2-5-1  

岡山大学大学院医歯学総合研究科口腔生理学分野

TEL086-235-6642  FAX086-235-6644     

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  教育

  研究

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  最近の業績

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教育

 生理学とはヒトの身体の持つ様々な機能(はたらき)を究明する自然科学の一つである。具体的には、我々の身体を構成している細胞、組織、器官のはたらきを運動力、電気、光、熱などの物理的現象を手がかりにして理解しようとする学問である。口腔生理学の講義と実習をとおして、生理学を良く理解し、病気にかかったときの変化を知ることができるようにしていきたい。

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研究

 本講座では顎顔面および口腔の生理機能を解明するため、とくに脳の研究に着目し、電気生理学的実験手技・免疫組織化学的実験手技・行動科学的実験手技を用いて神経系のメカニズムを明らかにする研究を行っている。

 主な研究テーマは、1)唾液分泌や血流を中心とした顎顔面の自律神経系の研究、2)摂食や飲水行動(食欲、のどの渇き、体液バランス)の中枢神経機構の研究、3)飲食物の嗜好や記憶に関する中枢神経機構の研究、4)口腔感覚(痛みや味覚)の神経機構の研究である。

 これらの研究テーマは決して独立したものではない。すなわち、顎顔面領域の運動系、自律系、感覚系が相互に関連し、中枢神経系がこれらを統合して生理機能が発揮されると考えられる。したがって大学院での研究指導にあたっては、中枢神経系全般の教育をおこなっている。また、大学院生は最新の電気生理学的実験手技を理解し今後の研究分野を把握する能力を身につける必要がある。このため、脳のスライス標本や培養標本を使用した分析的な神経生理学の研究方法を大学院教育に取り入れ、まず最新の電気生理学機器を利用できるように指導する。

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スタッフ

 

松尾龍二(教授)
小橋 基(准教授)
美藤純弘(助教)
藤田雅子(助手)

兒玉直紀(大学院生、咬合・口腔機能再建学分野)
古谷裕資(大学院生、開業医)
小橋美由紀(大学院生、博士課程)

植田紘貴(大学院生、顎顔面口腔矯正学分野)

松島あゆみ(大学院生、顎顔面口腔矯正学分野)

 

 

名誉教授

足立 明(初代教授) 足立先生の能面はこちら

 

非常勤講師  

大村 裕(九州大学名誉教授)

山本 隆(大阪大学人間科学部教授)

柴 芳樹(広島大学歯学部教授)

細井和雄(徳島大学歯学部教授)

稲永清敏(九州歯科大学教授)

井上富雄(昭和大学歯学部教授)

杉谷博士(日本大学松戸歯学部教授)

村上政隆(自然科学研究機構生理学研究所助教授)

(これまでにご来校いただきご講義を賜った先生方も含まれています)

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最近の業績(19982005

1. Adachi A & Kobashi M (1998) Role of hepatic afferent nerves in the control of saline and water intake. In: Liver and nervous system ( Eds. Haussinger D and Jun germann K) Kluwer academic publishers, Dordrecht, 209-219.

2. Funahashi M & Stewart M (1998) GABA receptor-mediated postsynaptic potentials in the retrohippocampal cortices: regional, laminar and cellular comparisons. Brain Res, 787: 19-33.

3. Funahashi M & Stewart M (1998) Properties of gamma-frequency oscillations initiated by propagating population bursts in retrohippocampal regions of rat brain slices. J Physiol Lond, 510: 191-208.

4. Kobashi M & Bradley RM (1998) Differences in the intrinsic membrane characteristics of parabrachial nucleus neurons processing gustatory and visceral information. Brain Res, 781: 215-223.

5. Kobashi M & Bradley R M (1998) Effects of GABA on neurons of the gustatory and visceral zones of the parabrachial nucleus in rats. Brain Res, 799: 323-328.

6. Kobashi M, Mizutani M & Adachi A (1998) Facilitation of gastric motility induced by portal infusion of hyper- and hypotonic solution in rats. J Autn Nerv Syst, 73: 156-162.

7. Matsuo R, Morimoto T & Kang Y (1998) Neural activity of the superior salivatory neucleus in rats. Eur J Morphol, 36: 203-207.

8. Matsuo R & Kang Y (1998) Two types of parasympathetic preganglionic neurones in the superior salivatory nucleus characterized electrophysiologically in slice preparations of neonatal rats. J Physiol Lond, 513: 157-170.

9. Sugimoto T, He Y-F , Funahashi M & Ichikawa H (1998) Induction of immediate-early genes c-fos and zif268 in the subnucleus oralis by noxious tooth pulp stimulation. Brain Res, 794: 353-358.

10. Kitada Y, Mitoh Y & Hill DL (1998) Salt taste response of the IXth nerve in Sprague-Dawley rats: lack of sensitivity of amiloride. Physiol Behav, 63: 945-949.

11. Matsuka Y, Kitada Y, Mitoh Y, Adachi A & Yamasita A (1998) Effects of a bite-raising splint on the dulation of the chewing cycle and the EMG activities of masticatory muscles during chewing in freely moving rabbits. J Oral Rehab, 25:159-165.

12. 北田泰之, 奥田-赤羽和久, 川原田啓, 美藤純弘 (1998) カエル舌咽神経の陽イオン応答に対するアミロライドの効果 日本味と匂学会誌 5: 501-504.

13. Kitada Y, Okuda-Akabane K, Kawarada K & Mitoh Y (1999) Effect of amiloride on the taste responses of the frog glossopharyngeal nerve to Ca, Mg and Na salts. In: Neurobiology of mastication - from molecular to systems approach (Eds. Nakamura Y and Sessle BJ) Elsevier Sciencepublishers, Amsterdam, 73-75.

14. Inoue T, Ogawa S, Itoh S, Matsuo R, Masuda Y, Komuro A, Hidaka O & Morimoto T (1999) Low-voltage activated calcium conductances in neonatal rat trigeminal motoneurons. In: Neurobiology of mastication - from molecular to systems approach (Eds. Nakamura Y and Sessle BJ) Elsevier Science publishers, Amsterdam, 83-85.

15. Itoh S, Inoue T, Kobayashi M, Kang Y, Ogawa S, Matsuo R, Wakisaka S, Takada K & Morimoto T (1999) Effects of serotonin on spike afterhyperpolarization in rat trigeminal motoneurons. In: Neurobiology of mastication - from molecular to systems approach (Eds. Nakamura Y and Sessle BJ) Elsevier Science publishers, Amsterdam, 86-88.

16.Matsuo R (1999) Discharge pattern of the superior salivatory nucleus in the rat:in vivo and in vitro studies. In: Neurobiology of mastication - from molecular to systems approach (Eds. Nakamura Y and Sessle BJ) Elsevier Science publishers, Amsterdam, 139-148.

17. Mizuno J, Matsuo R & Morimoto T (1999) Modulation of facial nerve discharge by tactile facial stimulation in the rat. In: Neurobiology of mastication - from molecular to systems approach (Eds. Nakamura Y and Sessle BJ) Elsevier Science publishers, Amsterdam, 432-434.

18. Inoue T, Itoh S, Kobayashi M, Kang Y, Matsuo R, Wakisaka S & Morimoto T (1999) Serotonergic modulation of the hyperpolarizing spike afterpotential in rat jaw-closing motoneurons by PKA and PKC. J Neurophysiol, 82: 626 637.

19. Matsuo R (1999) Central connections for salivary innervations and efferent impulse formation. In: Neural mechanisms of salivary gland secretion (Eds, Garrett JR, Ekstrom J and Anderson LC ) Front Oral Biol, Basel, Karger, 26-43.

20. Matsuo R (1999) Interrelation of taste and saliva. In Neural mechanisms of salivary gland secretion (Eds, Garrett JR, Ekstrom J and Anderson LC) Front Oral Biol, Basel, Karger, 185-195.

21. Funahashi M, He Y-F, Sugimoto T & Matsuo R (1999) Noxious tooth pulp stimulation suppresses c-Fos expression in the rat hippocampal formation. Brain Res, 827:215-220.

22. Funahashi M, Harris E & Stewart M (1999) Re-entrant activity in a presubiculum-subiculum circuit generates epileptiform activity in vitro. Brain Res, 849:139-146.

23. 松尾龍二 (1999) 行動中のラットにおける鼓索神経味応答の記録法. 日本味と匂学会誌6223-228.

24. 小橋基,松尾龍二,水谷雅年 (1999) 迷走神経節前ニューロンの喉頭化学刺激に対する応答性. 日本味と匂学会誌6: 595-598.

25. Matsuo R (2000) Role of saliva in the maintenance of taste sensitivity. Critical Reviews in Oral Biology and Medicine 11: 216-229.

26. Matuso R, Garrett JR, Proctor GB & Carpenter GH (2000) Reflex secretion of proteins into submandibular saliva in conscious rats, before and after preganglionic sympathectomy. J Physol Lond 527:175-184.

27. 小橋基,水谷雅年,古我知成 (2000) 末梢受容器による胃運動の調節とその神経メカニズム. 自律神経,37: 483-485.

28. Kobashi, M., Mizutani, M. and Matsuo, R (2000) Water stimulation of the posterior oral cavity induces inhibition of gastric motility. American Journal of Physiology: Regulatory Integrative Comparative Physiology, 279, R778-R785.

29. Yamada, Y., Tsukamoto, G., Kobashi, M., Sasaki, A. and Matsumura, T. : Abdominal vagi mediate c-Fos expression induced by X-ray irradiation in the nucleus tractus solitarii of the rat. Autonomic Neuroscience: Basic and Clinical, 83, 29-36, 2000.

30. Izawa S, Inoue K, Adachi A & Funahashi M (2000) Activity of neurons in the nucleus of the solitary tract of rats: effect of osmotic and mechanical stimuli. Neurosci Lett 288:33-36.

31. Funahashi M, Matsuo R and Stewart M (2000) Propagation of synchronous burst discharges from entorhinal cortex to morphologically and electro-physiologically identified neurons of rat lateral amygdala. Brain Res. 884:104-115, 2000

32. Matsuo R, Yamauchi Y, Kobashi M, Funahashi M, Mitoh Y and Adachi A (2001) Role of parabrachial nuclues in submandibular salivary secretion induced by bitter taste stimulation in rats. Auton. Neurosci. 88: 61-73

33. Masuda, Y., Kato, T., Hidaka, O., Matsuo, R., Inoue, T., Iwata, K. and Morimoto, T., Neural activity in the putamen and the globus pallidus of rabbit during mastication. Neurosci. Res., 39: 11-19, 2001.

34. Kohjitani A, Miyawaki T, Funahashi M, Mitoh Y, Matsuo R, Shimada M (2001) Intravenous anesthetics inhibit nonadrenergic noncholinergic lower esophageal sphincter relaxation via nitric oxcide-cyclic guanosine monophosphate pathway modulation in rabbits, Anesthesiology, 95:176-182

35. Funahashi M, Higuchi H, Miyawaki T, Shimada M, Matsuo R (2001) Propofol suppresses a hyperpolarization-activated inward current in rat hippocampal CA1 neurons, Neuroscience Letters, 311: 177-180

36. Kitada Y., Okuda-Akabane K. and Mitoh Y. (2001) Effects of amiloride on gustatory neural responses to salts in the frog. Chem Senses, in press

37. 小橋基、柳原 衛、水谷雅年、松尾龍二 (2001) 上喉頭神経刺激による迷走神経背側核ニューロンのc-fos発現, 日本味と匂学会誌 8: 555-558

38. Kobashi M, Koga T, Mizutani M, and Matsuo R (2002) Suppression of vagal motor activities evokes laryngeal afferent-mediated inhibition of gastric motility. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, in press

39. Funahashi M, Matsuo R and Stewart M (2002) Long-term enhancement of excitatory synaptic inputs to layer V parahippocampal neurons by low frequency stimulation in rat brain slices. Neuroscience Research, 42(1): 65-77

40. Funahashi M, Mitoh Y and Matsuo R (2002) Two distinct types of transient outward currents in area postrema neurons in rat brain slices. Brain Research, in press

41. Funahashi M, Mitoh Y, and Matsuo R, Electrophysiological properties of the rat area postrema neurons displaying both the transient outward current and the hyperpolarization-activated inward current. Brain Research Bulletin 58(3): 337-343, 2002

42. Kobashi M, Furudono Y, Matsuo R, Yamamoto T. Related Articles, Central orexin facilitates gastric relaxation and contractility in rats. Neuroscience Letters 332(3):171-4, 2002.

43. 舩橋 誠,傍海馬領域の同期性神経活動の伝播による扁桃体外側核神経活動の修飾。歯科基礎医学会誌,2002Funahashi M, Modulation of neural activity in the lateral nucleus of the amygdala by the propagation of synchronous burst discharges from parahippocampal neurons. Japanese Journal of Oral Biology, 44:195-202, 2002 総説(学会賞受賞) 

44. Koga T, Kobashi M, Mizutani M, Tsukamoto G, Matsuo R. Area postrema mediates gastric motor response induced by apomorphine in rats.Brain Res, 960:122-31, 2003.

45. Higuchi H, Funahashi M, Miyawaki T, Mitoh Y, Kohjitani A, Shimada M and Matsuo R, Depressant effect of propofol on the neuronal activity of rat hippocampal CA1 neurons via the hyperpolarization-activated channel and glutamatergic synaptic transmission. Neurosicence Research, 45(4): 459-472, 2003.

46. Kohjitani A, Miyawaki T, Funahashi M, Higuchi H, Matsuo R, Shimada M. Ketamine and Midazolam Differentially Inhibit Nonadrenergic Noncholinergic Lower Esophageal Sphincter Relaxation in Rabbits: Role of Superoxide Anion and Nitric Oxide Synthase. Anesthesiology, Feb;98(2):449-458, 2003.

47. Matsuo R, Mitoh Y, Funahashi M, Kobashi M, Morphological study on the superior salivatory nucleus innervating the submandibular and sublingual salivatory glands and tongue in rats. Dentistry in Japan, 39: 34-36, 2003.

48. Funahashi M, Mitoh Y, Kohjitani A and Matsuo R, Role of the hyperpolarization-activated cation current (Ih) for pacemaker activity in area postrema neurons of rat brain slices. Journal of Physiology (Lond), 552.1: 135-148, 2003

49. Kohjitani A, Miyawaki T, Funahashi M, Mitoh Y, Matsuo R, Shimada M. Mexiletine inhibits nonadrenergic noncholinergic lower oesophageal sphincter relaxation in rabbits. European Journal of Pharmacology 465: 145-151, 2003.

50. Funahashi M, Role of the cyclic nucleotide-gated channels in pacemaker activity in the central nervous system. Novartis Foundation (Japan) for the Promotion of Science Annual Report pp.75-77, 2003.

51. 樋口仁,舩橋 誠,宮脇卓也,美藤純弘,糀谷 淳,嶋田昌彦,松尾龍二. プロポフォールの中枢神経抑制作用に関する電気生理学的研究。岡山歯学会雑誌 22:165-17, 2003.

52. Mitoh Y, Funahashi M, Kobashi M, Matsuo R. Excitatory and inhibitory postsynaptic currents of the superior salivatory nucleus innervating the salivary glands and tongue in the rat. Brain Research, 999:62-72, 2004

53. Funahashi M, Mitoh Y and Matsuo R, The sensitivity of hyperpolarization-activated cation current (Ih) to propofol in rat area postrema neurons. Brain Research 1015(1-2):198-201, 2004

54. Funahashi M, Mitoh Y and Matsuo R, Nicotinic modulation of area postrema neuronal excitability in rat brain slices. Brain Research 1017(1-2): 227-233, 2004

55. Funahashi M, Mitoh Y and Matsuo R, Activation of presynaptic 5-HT3 receptors facillitates glutamatergic synaptic transmission in rat area postrema neurons. Methods and Findings in Experimental and Clinical Pharmacology, 26(8):615-622, 2004

56. 舩橋 誠,松尾龍二. 最後野ニューロンのペースメーカー活性/過分極作動性内向きカチオン電流による制御。生体の科学特集 脳の深部を探る。55(6): 323-328, 2004

57. Kobashi M, Koga T, Mizutani M and Matsuo R, Neural mechanism and possible role of inhibition of gastric motility induced by superior laryngeal afferents. Chemical Senses Suppl 1:i72-i73, 2005

58. Kobashi Miyuki, Ichikawa H, Kobashi M, Funahashi M, Mitoh Y and Matsuo R, The origin of sensory nerve fibers that innervate the submandibular salivary gland in the rat. Brain Research 1060(1-2):184-7, 2005

59. Funahashi M, Mitoh Y, Akaike T and Matsuo R, Variety of morphological and electrophysiological properties of area postrema neurons in adult rat brain slices. Neuroscience Research, in press (2005)

60. Kohjitani A, Funahashi M, Miyawaki T, Hanazaki M, Matsuo R and Shimada M, Peripheral N-Methyl-d-Aspartate Receptors Modulate Nonadrenergic Noncholinergic Lower Esophageal Sphincter Relaxation in Rabbits. Anesthesia and Analgesia 101(6):1681-8, 2005

61. Kobashi M, Shimatani Y, Shirota K, Xuan SY, Mitoh Y and Matsuo R, Central neuropeptide Y induces proximal stomach relaxation via Y1 receptors in the dorsal vagal complex of the rat. American Journal of Physiology- Reguratory Integrative and Comparative Physiology 290:R290-7, 2006

62. 松尾龍二. 唾液分泌の中枢制御機構。日本薬理学会雑誌, 127:261-62006

63. 松尾龍二. 口腔の生理から?を解く〜どうして唾液がサラサラしたり、ネバネバしたりするのだろうか?〜。デンタルダイヤモンド,31(8):76-9, 2006

64. 松尾龍二. 行動学的,神経生理学的にみた咀嚼と唾液分泌の関係。日本咀嚼学会雑誌,16(2):39-47, 2006

65. 松尾龍二. おいしく食べるための唾液分泌。矯正Year Book06, 50-2, 2006

66. 松尾龍二. イラストでわかる歯科医学の基礎。45-63,2006

67. 松尾龍二,小橋基. 咀嚼と味覚,消化吸収。咀嚼の事典,63-76, 2007

68. 松尾龍二.  唾液の抗微生物作用について。日本医事新報,4343:97-82007

69. Mese H, Matsuo R, Salivary secretion, taste and hyposalivation. Journal of Oral Rehabilitation 34: 711-23, 2007

70.  Kodama N, Funahashi M, Mitoh Y, Minagi S and Matsuo R, Purinergic modulation of area postrema neuronal excitability in rat brain slices. Brain Research 1165: 50-59, 2007

71. 松尾龍二.  2章 ドライマウスに関連する疾患と病態ならびに対処法。唾液の役割「ドライマウスの臨床」,180-42007

72. Mitoh Y, Funahashi M, Fujii A, Fujita M, Kobashi M and Matsuo R, Development of inhibitory synaptic transmission to the superior salivatory nucleus in rats. (in press)

 

 

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最終更新日 : 2005.2.17